CAJ | 학술논문

目的：对改良FOLFOX6新辅助化疗与术后化疗治疗进展期胃癌的临床疗效进行对比分析。方法选取200例进展期胃癌患者，并将其随机分为2组，改良FOLFOX6新辅助化疗组和改良FOLFOX6术后辅助化疗组，以进行单纯手术的100例为对照组，对比观察术后的临床疗效以及围术期并发症情况。结果改良FOLFOX6新辅助化疗组治疗后患者的总有效率（87．00％）明显高于改良FOLFOX6术后辅助化疗组患者的总有效率（57．00％），统计学上有意义（P＜0．05）。同时，改良FOLFOX6新辅助化疗组患者的手术后围术期并发症发生率（22．00％）明显低于单纯手术治疗组并发症发生率（49．00％），差异在统计学上有意义（P＜0．05）。结论改良FOLFOX6新辅助化疗对进展期胃癌的临床治疗效果较改良FOLFOX6术后辅助化疗的治疗效果显著，围术期并发症较少，安全可靠，可以在临床上广泛应用。
목적：대개량FOLFOX6신보조화료여술후화료치료진전기위암적림상료효진행대비분석。방법선취200례진전기위암환자，병장기수궤분위2조，개량FOLFOX6신보조화료조화개량FOLFOX6술후보조화료조，이진행단순수술적100례위대조조，대비관찰술후적림상료효이급위술기병발증정황。결과개량FOLFOX6신보조화료조치료후환자적총유효솔（87．00％）명현고우개량FOLFOX6술후보조화료조환자적총유효솔（57．00％），통계학상유의의（P＜0．05）。동시，개량FOLFOX6신보조화료조환자적수술후위술기병발증발생솔（22．00％）명현저우단순수술치료조병발증발생솔（49．00％），차이재통계학상유의의（P＜0．05）。결론개량FOLFOX6신보조화료대진전기위암적림상치료효과교개량FOLFOX6술후보조화료적치료효과현저，위술기병발증교소，안전가고，가이재림상상엄범응용。
Objective To compare the clinical efficacy of improved FOLFOX 6 neoadjuvant chemotherapy and postopera-tive chemotherapy for advanced gastric carcinoma .Methods 200 patients with advanced gastric carcinoma were randomly divid-ed into improved FOLFOX6 neoadjuvant chemotherapy group and postoperative chemotherapy group ,each with 100 cases.100 pa-tients who received surgery was the control group ,clinical efficacy and perioperative complications of patients were compared and observed.Results Total effective rate of improved FOLFOX6 neoadjuvant chemotherapy group after treatment (87.00%) was significantly higher than that of postoperative chemotherapy group (57.00%),there had statistical difference (P<0.05).And complication rate of improved FOLFOX6 neoadjuvant chemotherapy group (22.00%) was significantly lower than that of postoper-ative chemotherapy group(49.00%),there had statistical difference (P<0.05).Conclusion Improved FOLFOX6 neoadjuvant chemotherapy for advanced gastric carcinoma is more effective than postoperative chemotherapy with less perioperative complica -tions.It is safe and reliable ,and can be widely promoted in clinic .