CAJ | 학술논문

目的：探讨鼻咽癌（ NPC）组织中淋巴管密度（ LVD）与其淋巴结转移的关系。方法应用单克隆抗体D2-40免疫组化法，检测66例NPC组织中的淋巴管密度，另选取30例轻度鼻咽黏膜炎的鼻咽组织作为对照，分析LVD与肿瘤淋巴结转移的关系。结果鼻咽癌组织LVD高于对照组（P＜0．05）；鼻咽癌组织瘤周LVD明显高于瘤内LVD（P＜0．01）；淋巴结转移患者NPC瘤周LVD高于无淋巴结转移者（P＜0．05）；瘤周LVD与鼻咽癌N分期的升高呈一致性（P＜0．05）；此外，瘤周LVD与鼻咽癌患者年龄、性别、远处转移、临床分期及T分期无相关性（P＞0．05），年龄＜49岁的NPC患者瘤内LVD高于年龄≥49岁的患者（P＜0．05）；瘤内LVD与患者性别、肿瘤T分期、N分期、M分期及临床分期无相关性（P＞0．05）。结论鼻咽癌瘤周LVD与淋巴结转移密切相关，推测瘤周LVD对该肿瘤发生颈部淋巴结转移具有重要意义。
목적：탐토비인암（ NPC）조직중림파관밀도（ LVD）여기림파결전이적관계。방법응용단극륭항체D2-40면역조화법，검측66례NPC조직중적림파관밀도，령선취30례경도비인점막염적비인조직작위대조，분석LVD여종류림파결전이적관계。결과비인암조직LVD고우대조조（P＜0．05）；비인암조직류주LVD명현고우류내LVD（P＜0．01）；림파결전이환자NPC류주LVD고우무림파결전이자（P＜0．05）；류주LVD여비인암N분기적승고정일치성（P＜0．05）；차외，류주LVD여비인암환자년령、성별、원처전이、림상분기급T분기무상관성（P＞0．05），년령＜49세적NPC환자류내LVD고우년령≥49세적환자（P＜0．05）；류내LVD여환자성별、종류T분기、N분기、M분기급림상분기무상관성（P＞0．05）。결론비인암류주LVD여림파결전이밀절상관，추측류주LVD대해종류발생경부림파결전이구유중요의의。
Objective To investigate the correlation between lymphatic vessel density ( LVD) andlymph node metastasis in nasopharyngeal carcinoma .Methods Lymphatic vessel density of 66 nasopharyngeal carcinoma patients were detected by monoclonal antibody D 2-40 immunohistochemistry .30 patients with mild nasopharyngitis were selected as the control group .The correlation between LVD and lymph node metastasis were analyzed .Results The LVD in nasopharyngeal carcinoma were signifi-cantly higher than that of the control group (P<0.05);The peritumoral LVD in nasopharyngeal carcinoma were significantly high-er than intratumoral LVD ( P<0.01);pLVD increased with the N stage of tumor ( P<0.05);pLVD had no relation with age ,sex, metastasis,T and clinical stages(P>0.05);The patients under 49 had significantly higher intratumoral LVD than patients over 49(P<0.05);and intratumoral LVD had no relationwith sex ,metastasis,T,N,M and clinical stages(P>0.05).Conclusion Peritumoral LVD has a colse relationship withlymph node metastasis in NPC ,and it is of great importance for the neck lymph node metastasis of the NPC .