CAJ | 학술논문

目的：探讨LIMK1表达和结肠癌患者临床病理特征的关系。方法将68例结肠癌、17例上皮内瘤变及31例正常结肠组织共116例结肠标本制成组织芯片，采取免疫组织化学技术检测标本中LIMK1的表达水平。结果LIMK1在结肠癌中的表达水平显著高于健康组织。 LIMK1表达与结肠癌肿瘤大小、淋巴结转移、TNM分期有关（ P＜0．05），但与患者的年龄、分化程度无关。结论 LIMK1表达与结肠癌的发生发展密切相关，可能是结肠癌侵袭转移的重要标志。
목적：탐토LIMK1표체화결장암환자림상병리특정적관계。방법장68례결장암、17례상피내류변급31례정상결장조직공116례결장표본제성조직심편，채취면역조직화학기술검측표본중LIMK1적표체수평。결과LIMK1재결장암중적표체수평현저고우건강조직。 LIMK1표체여결장암종류대소、림파결전이、TNM분기유관（ P＜0．05），단여환자적년령、분화정도무관。결론 LIMK1표체여결장암적발생발전밀절상관，가능시결장암침습전이적중요표지。
Objective To investigate the relations between LIMK 1 expression and clinicopathological features of human colon cancer .Methods Immunohistochemistry method was used to examine the expression of LIMK 1 in colon cancer ( 68 ca-ses),adenoma(17 cases)and normal tissue(31 cases).Results The expression of LIMK1 in human colon cancer was signifi-cantly higher than that of the normal tissue .LIMK1 expression was related to tumor size ,lymph node metastasis ,and TNM stage( P<0.05),but it was unrelated to age and the degree of differentiation .Conclusion The expression of LIMK1 is closely related to carcinogenesis and development of colon cancer ,and it may be an important biomarker of metastasis of colorectal carcinoma .