CAJ | 학술논문

目的：探讨宫颈上皮内瘤变（ CIN）及宫颈癌组织中EZH2的表达及其意义。方法应用免疫组织化学S-P法，检测65例宫颈癌、90例CIN、30例正常宫颈组织中EZH2的表达水平。结果在正常宫颈组织、CIN组织、宫颈癌组织中，EZH2阳性表达率分别为13．3％（4／30）、CINⅠ组30．0％（9／30）、CINⅡ组40．0％（12／30）、CINⅢ组56．7％（17／30）和76．9％（50／65）。 CIN和宫颈癌中EZH2阳性表达率均明显高于正常宫颈组织，差异均具有统计学意义（ P＜0．001）。结论 EZH2参与了宫颈癌的发生、发展，可作为宫颈病变早期诊断的生物学指标，可提高宫颈癌的早期诊断率。
목적：탐토궁경상피내류변（ CIN）급궁경암조직중EZH2적표체급기의의。방법응용면역조직화학S-P법，검측65례궁경암、90례CIN、30례정상궁경조직중EZH2적표체수평。결과재정상궁경조직、CIN조직、궁경암조직중，EZH2양성표체솔분별위13．3％（4／30）、CINⅠ조30．0％（9／30）、CINⅡ조40．0％（12／30）、CINⅢ조56．7％（17／30）화76．9％（50／65）。 CIN화궁경암중EZH2양성표체솔균명현고우정상궁경조직，차이균구유통계학의의（ P＜0．001）。결론 EZH2삼여료궁경암적발생、발전，가작위궁경병변조기진단적생물학지표，가제고궁경암적조기진단솔。
Objective To investigate the expression and significance of EZH 2 in CIN and cervical carcinoma .Methods The expression of EZH2 in 65 cases of cervical carcinoma ,90 cases of CIN and 30 cases of normal cervical were detected by epi-thelia immunohisochemical SP method .Results Positive rates of EZH2 were 13.3% (4/30),30.0% (9/30),40.0% (12/30),56.7%(17/30) and 76.9%(50/65) in the normal cervical epithelia ,CINⅠgroup,CINⅡgroup,CINⅢgroup and cer-vical carcinoma ,respectively .The positive expression of EZH 2 in CIN and cervical carcinoma was significantly higher than that of the normal tissues,the difference was statistically significant (P<0.001).Conclusion EZH2 is involved in the development of cervical carcinoma ,and may be biological predictor for early diagnosis .