CAJ | 학술논문

目的：探讨甲状腺透明变梁状肿瘤( hyalinizing trabecudar tumor, HTT)临床病理学特征、鉴别诊断及治疗。方法回顾分析6例HTT的临床表现、超声检查、组织病理学及免疫表型特征,并复习相关文献。结果组织病理学显示瘤细胞呈梁状、器官样排列,小梁间见透明变性的基膜样物质沉积,细胞呈多角形或梭形；胞质嗜酸,细颗粒状,胞核圆形或卵圆形,常见核沟及核内假包涵体。免疫组化标记瘤细胞TG、TTF-1、CD56呈阳性,CK19散在(+),Galectin-3(-/+),不表达Calcitonin、MC、CEA、Syn、CgA,Ki-67表达膜阳性或质弱阳性,p53低表达。该肿瘤需与甲状腺乳头状癌、甲状腺髓样癌和副神经节瘤等相鉴别。结论 HTT是一种罕见的甲状腺肿瘤,多表现为良性的形态学及生物学行为,准确的病理学诊断对其临床治疗及预后有极其重要的作用。
목적：탐토갑상선투명변량상종류( hyalinizing trabecudar tumor, HTT)림상병이학특정、감별진단급치료。방법회고분석6례HTT적림상표현、초성검사、조직병이학급면역표형특정,병복습상관문헌。결과조직병이학현시류세포정량상、기관양배렬,소량간견투명변성적기막양물질침적,세포정다각형혹사형；포질기산,세과립상,포핵원형혹란원형,상견핵구급핵내가포함체。면역조화표기류세포TG、TTF-1、CD56정양성,CK19산재(+),Galectin-3(-/+),불표체Calcitonin、MC、CEA、Syn、CgA,Ki-67표체막양성혹질약양성,p53저표체。해종류수여갑상선유두상암、갑상선수양암화부신경절류등상감별。결론 HTT시일충한견적갑상선종류,다표현위량성적형태학급생물학행위,준학적병이학진단대기림상치료급예후유겁기중요적작용。
Purpose To explore the clinical pathological features and differential diagnoses and therapeutics of hyalinizing trabecular tumours ( HTT) of thyroid. Methods The clinical manifestations, high-frequency color doppler ultrasonography, histopathological and immunohistochemical features were analysed in six cases of HTT of thyroid. Related literatures were reviewed. Results On his-topathological examination, polygonal and elongated cells arranged in pattern of trabecular and organoid, with a clear perinucleolus ha-lo. Basement membrane-like material deposited intertrabeculae widespreadly. The tumour cells are completely filled with eosinophilic and granular material in their cytoplasm, nuclei with prominent grooves and pseudoinclusions. Immunohistochemically, the tumour cells were positive for TG, TTF-1 and CD56, CK19 and Galectin-3 interspersed expression. And all of them were negative for Calcito-nin, MC, CEA, Syn, CgA, Ki-67, p53 were lower expression. The differential diagnosis included solid variant of papillary carcinoma, medullary thyroid carcinoma and paraganglioma and so on. Conclusion HTT is an uncommon thyroid tumor, the majority of them be-have as benign neiplasms and that, correct pathologic diagnosis may play an important role in standard treatment and prognostic evalua-tion of HTT.