实用口腔医学杂志
實用口腔醫學雜誌
실용구강의학잡지
JOURNAL OF PRACTICAL STOMATOLOGY
2014年
5期
698-700
,共3页
口腔扁平苔藓%T淋巴细胞%干扰素-γ%白介素-4%白介素-17
口腔扁平苔蘚%T淋巴細胞%榦擾素-γ%白介素-4%白介素-17
구강편평태선%T림파세포%간우소-γ%백개소-4%백개소-17
Oral lichen planus%T lymphocyte%Interferon-γ%Interleukin-4%Interleukin-17
目的：探讨Th1、Th2、Th17代表性细胞因子IFN-γ、IL-4、IL-17在口腔扁平苔藓（OLP）发病中的作用及意义。方法：采用ELISA法测定60例OLP患者（糜烂型30例，非糜烂型30例）及25例健康人血清中IFN-γ、IL-4、IL-17表达水平，并分析其与OLP临床特征相关性。结果：IFN-γ表达水平在非糜烂型及糜烂型OLP组均低于对照组（P＜0．01）；IL-4表达水平在非糜烂型及糜烂型OLP组均高于对照组（P＜0．01）；IFN-γ／IL-4比值水平在非糜烂型和糜烂型OLP组均低于正常对照组（P＜0．01）。IL-17表达水平在糜烂型OLP组高于对照组（P＜0．05）；非糜烂型OLP组与对照组差异无统计学意义（P＞0．05）。结论：IFN-γ表达降低和IL-4表达增高导致IFN-γ／IL-4比值降低是OLP的免疫病因学因素之一，IL-17蛋白表达增高主要与糜烂型OLP炎症过程有关。
目的：探討Th1、Th2、Th17代錶性細胞因子IFN-γ、IL-4、IL-17在口腔扁平苔蘚（OLP）髮病中的作用及意義。方法：採用ELISA法測定60例OLP患者（糜爛型30例，非糜爛型30例）及25例健康人血清中IFN-γ、IL-4、IL-17錶達水平，併分析其與OLP臨床特徵相關性。結果：IFN-γ錶達水平在非糜爛型及糜爛型OLP組均低于對照組（P＜0．01）；IL-4錶達水平在非糜爛型及糜爛型OLP組均高于對照組（P＜0．01）；IFN-γ／IL-4比值水平在非糜爛型和糜爛型OLP組均低于正常對照組（P＜0．01）。IL-17錶達水平在糜爛型OLP組高于對照組（P＜0．05）；非糜爛型OLP組與對照組差異無統計學意義（P＞0．05）。結論：IFN-γ錶達降低和IL-4錶達增高導緻IFN-γ／IL-4比值降低是OLP的免疫病因學因素之一，IL-17蛋白錶達增高主要與糜爛型OLP炎癥過程有關。
목적：탐토Th1、Th2、Th17대표성세포인자IFN-γ、IL-4、IL-17재구강편평태선（OLP）발병중적작용급의의。방법：채용ELISA법측정60례OLP환자（미란형30례，비미란형30례）급25례건강인혈청중IFN-γ、IL-4、IL-17표체수평，병분석기여OLP림상특정상관성。결과：IFN-γ표체수평재비미란형급미란형OLP조균저우대조조（P＜0．01）；IL-4표체수평재비미란형급미란형OLP조균고우대조조（P＜0．01）；IFN-γ／IL-4비치수평재비미란형화미란형OLP조균저우정상대조조（P＜0．01）。IL-17표체수평재미란형OLP조고우대조조（P＜0．05）；비미란형OLP조여대조조차이무통계학의의（P＞0．05）。결론：IFN-γ표체강저화IL-4표체증고도치IFN-γ／IL-4비치강저시OLP적면역병인학인소지일，IL-17단백표체증고주요여미란형OLP염증과정유관。
Objective:To study the expression of IFN-γ,IL-4 and IL-17 in peripheral blood of patients with oral lichen planus(OLP). Methods:The level of IFN-γ,IL-4 and IL-17 in peripheral blood were detected by ELISA in 60 OLP patients(including 30 erosive ca-ses and 30 non-erosive cases)and 25 healthy volunteers(controls).Data were statistically analyzed by SPSS 13.0.Results:(1 )The level of IFN-γin serum of patients with non-erosive OLP and erosive OLP were significantly lower than that in the controls(P<0.01);while the level of IL-4 in the patients were significantly higher than that in the controls(P<0.01),and the IFN-γ/IL-4 ratio in non-ero-sive OLP and erosive groups were significantly lower than that in the control group(P<0.01);(2)The level of IL-17 in erosive OLP pa-tients was significantly higher than that in the controls(P<0.05),while no statistical difference was seen between non-erosive OLP group and the control group(P>0.05).Conclusion:The down-regulated level of IFN-γand up-regulated level of IL-4,which result in the decrease of IFN-γ/IL-4 ratio,might be one of the immune etiological factors of OLP,while the up-regulated level of IL-17 protein in OLP may be mainly related with the inflammatory processes of OLP.
