CAJ | 학술논문

目的：分析口腔扁平苔藓（OLP）患者免疫状况与临床特征的关系。方法：用流式细胞术及散射比浊法分别检测197例OLP患者（网纹型61例，充血糜烂型136例）细胞免疫（CD3＋、CD4＋、CD8＋、CD19＋、CD16＋＋56＋、CD4＋／CD8＋）及体液免疫（IgG、IgA、IgM、C3、CH50）状况。结果：与实验室标准正常值相比，OLP患者CD3＋、CD4＋降低，CD19＋增高；IgG、IgM、CH50增高，IgA、C3降低。网纹型OLP患者 CD16＋＋56＋、CD4＋／CD8＋低于正常值；充血糜烂型OLP患者CD8＋低于正常值。充血糜烂型OLP患者CD3＋、CD8＋较网纹型降低，CD4＋／CD8＋较网纹型升高（P＜0．05）。结论：OLP患者存在不同程度的细胞免疫功能降低，体液免疫功能紊乱，以亢进为主。不同临床类型的OLP患者免疫状况存在一定的差别。
목적：분석구강편평태선（OLP）환자면역상황여림상특정적관계。방법：용류식세포술급산사비탁법분별검측197례OLP환자（망문형61례，충혈미란형136례）세포면역（CD3＋、CD4＋、CD8＋、CD19＋、CD16＋＋56＋、CD4＋／CD8＋）급체액면역（IgG、IgA、IgM、C3、CH50）상황。결과：여실험실표준정상치상비，OLP환자CD3＋、CD4＋강저，CD19＋증고；IgG、IgM、CH50증고，IgA、C3강저。망문형OLP환자 CD16＋＋56＋、CD4＋／CD8＋저우정상치；충혈미란형OLP환자CD8＋저우정상치。충혈미란형OLP환자CD3＋、CD8＋교망문형강저，CD4＋／CD8＋교망문형승고（P＜0．05）。결론：OLP환자존재불동정도적세포면역공능강저，체액면역공능문란，이항진위주。불동림상류형적OLP환자면역상황존재일정적차별。
Objective:To analyze the characteristics of immune status in patients with different types of oral lichen planus(OLP). Methods:197 cases of OLP,61 with reticular OLP(ROLP)and 136 with hyperaemia erosion OLP(HEOLP)were included.The im-mune status of the patients were investigated by flow cytometry (FCM)for the expression of CD3 +,CD4 +,CD8 +,CD19 +,CD16 ++56 +and CD4 +/CD8 +cells,and nephelometry for the measurements of IgG,IgA,IgM,C3 and CH50 in peripheral blood.The la-brotary norm was used as the reference and the characteristics of immune status in patients with different clinical characters of OLP were analyzed by SPSS 16.0.Results:CD3 +,CD4 +,IgA and C3 decreased,CD19 +cells,IgG,IgMand CH50 increased in patients with OLP.CD16 ++56 +,CD4 +/CD8 +cells decreased in the cases with ROLP(P<0.05);CD8 +cells decreased in the cases with HE-OLP.CD3 +,CD8 +cells were fewer in HEOLP patients than that in ROLP,CD4 +/CD8 +cells were more in HEOLP than that in ROLP(P<0.05).Conclusion:There are defects of cellular immune function and increase of humoral immune in patients with OLP. The patients with different clinical types of OLP may have different immune fuction changes.