中国临床神经科学
中國臨床神經科學
중국림상신경과학
CHINESE JOURNAL OF CLINICAL NEUROSCIENCES
2014年
5期
530-534
,共5页
冼文彪%江璐璐%刘妍梅%史新冲%郑一帆%张祥松%唐刚华%裴中%黎锦如%刘焯霖%陈玲
冼文彪%江璐璐%劉妍梅%史新遲%鄭一帆%張祥鬆%唐剛華%裴中%黎錦如%劉焯霖%陳玲
승문표%강로로%류연매%사신충%정일범%장상송%당강화%배중%려금여%류작림%진령
帕金森病%正电子发射断层显像%脑代谢%多巴胺转运体
帕金森病%正電子髮射斷層顯像%腦代謝%多巴胺轉運體
파금삼병%정전자발사단층현상%뇌대사%다파알전운체
Parkinson’s disease%positron emission tomography%cerebral metabolism%dopamine transporter
目的探讨[18F]FDG脑代谢联合[11C]CFT脑多巴胺转运体(DAT)正电子发射断层显像(PET)对帕金森病(PD)诊断及病情严重度评估的应用价值。方法对30例PD患者(PD组)进行[18F]FDG脑代谢显像和[11C]CFT脑DAT PET显像检查，同时采用帕金森病统一评分量表第三部分(UPDRS Ⅲ)的运动评分和Hoehn-Yahr(H-Y)分期对纳入研究PD患者的临床症状进行评分，分析[18F]FDG PET、[11C]CFT PET和临床评分之间的相关性。选取年龄匹配的健康受试者10名为对照组。结果[18F]FDG PET提示PD组普遍存在苍白球、丘脑、脑干、小脑、感觉运动皮质区代谢增强和运动前皮质、顶枕区代谢减弱的PD相关代谢模式(PDRP)，PDRP评分与发病年龄和H-Y分期评分存在显著正相关。[11C]CFT PET提示PD组存在尾状核、壳核DAT摄取值较对照组下降，纹状体DAT摄取值和UPDRSⅢ评分、H-Y分期和PDRP评分存在显著负相关。结论[11C]CFT与[18F]FDG PET显像联合检查有助于PD诊断和病情严重度的评估。
目的探討[18F]FDG腦代謝聯閤[11C]CFT腦多巴胺轉運體(DAT)正電子髮射斷層顯像(PET)對帕金森病(PD)診斷及病情嚴重度評估的應用價值。方法對30例PD患者(PD組)進行[18F]FDG腦代謝顯像和[11C]CFT腦DAT PET顯像檢查，同時採用帕金森病統一評分量錶第三部分(UPDRS Ⅲ)的運動評分和Hoehn-Yahr(H-Y)分期對納入研究PD患者的臨床癥狀進行評分，分析[18F]FDG PET、[11C]CFT PET和臨床評分之間的相關性。選取年齡匹配的健康受試者10名為對照組。結果[18F]FDG PET提示PD組普遍存在蒼白毬、丘腦、腦榦、小腦、感覺運動皮質區代謝增彊和運動前皮質、頂枕區代謝減弱的PD相關代謝模式(PDRP)，PDRP評分與髮病年齡和H-Y分期評分存在顯著正相關。[11C]CFT PET提示PD組存在尾狀覈、殼覈DAT攝取值較對照組下降，紋狀體DAT攝取值和UPDRSⅢ評分、H-Y分期和PDRP評分存在顯著負相關。結論[11C]CFT與[18F]FDG PET顯像聯閤檢查有助于PD診斷和病情嚴重度的評估。
목적탐토[18F]FDG뇌대사연합[11C]CFT뇌다파알전운체(DAT)정전자발사단층현상(PET)대파금삼병(PD)진단급병정엄중도평고적응용개치。방법대30례PD환자(PD조)진행[18F]FDG뇌대사현상화[11C]CFT뇌DAT PET현상검사，동시채용파금삼병통일평분량표제삼부분(UPDRS Ⅲ)적운동평분화Hoehn-Yahr(H-Y)분기대납입연구PD환자적림상증상진행평분，분석[18F]FDG PET、[11C]CFT PET화림상평분지간적상관성。선취년령필배적건강수시자10명위대조조。결과[18F]FDG PET제시PD조보편존재창백구、구뇌、뇌간、소뇌、감각운동피질구대사증강화운동전피질、정침구대사감약적PD상관대사모식(PDRP)，PDRP평분여발병년령화H-Y분기평분존재현저정상관。[11C]CFT PET제시PD조존재미상핵、각핵DAT섭취치교대조조하강，문상체DAT섭취치화UPDRSⅢ평분、H-Y분기화PDRP평분존재현저부상관。결론[11C]CFT여[18F]FDG PET현상연합검사유조우PD진단화병정엄중도적평고。
Aim To evaluate the application of [18F]FDG cerebral metabolism and [11C]CFT dopamine transporter (DAT) positron emission tomography (PET) imaging in diagnosing and assessing the severity of Parkinson’s disease (PD).Methods [18F]FDG and [11C]CFT PET imaging were performed and analyzed for 30 PD patients. The uniifed Parkinson’s disease rating scale motor score (UPDRSⅢ) and Hoehn &Yahr (H-Y) scale were used to evaluate the clinical state. The correlation between PET results with clinical rating scores was evaluated by calculating Pearson’s regression coefifcient. Ten Cases whose age matched healthy subjects were seleeted as the control group.Results [18F]FDG PET imaging of PD patients showed metabolic increased in the pallidum, thalamus, pons, cerebellum and sensorimotor cortex, with metabolic decreased in the lateral premotor cortex and parieto-occipital association regions, which was called PD-related motor pattern (PDRP). The PDRP scores showed signiifcant correlation with PD patients’ on-set age and H&Y scores. [11C]CFT PET imaging showed the DAT uptake in the caudate and putamen were signiifcantly reduced in PD patients. The DAT uptake in the caudate and putamen showed signiifcantly negative correlation with the UPDRSⅢ scores, H&Y scores and PDRP scores.Conclusion Combination application of [18F]FDG and [11C]CFT PET imaging could be served as a sensitive biomarker in the diagnosis and assessment of the disease severity of PD.
