CAJ | 학술논문

目的探讨中高强度有氧运动疗法对阿尔茨海默病(AD)患者的干预作用。方法将52例AD患者分为中等强度有氧运动(中等强度)组(13例)、高强度有氧运动(高强度)组(13例)和对照组(26例)。所有入组患者均按AD常规治疗，中等强度组和高强度组分别接受强度为50%和70%最大运动能力的有氧运动训练12周，每周3次。于治疗前、治疗后8和12周对3组患者进行AD相关量表(MMSE、ADCS-ADL、NPI、NPI-D和ADAS-cog)评价，同时进行体格检查、血常规、血生化常规等检查。结果中等强度组、高强度组有氧运动能明显改善患者的认知能力和精神神经症状，与对照组比较差异有统计学意义(P<0.05)；中等强度组和高强度组有氧运动对患者日常生活活动能力无有益影响。第8周，高强度组MMSE和NPI评分较中等强度组改善更多(P<0.05)；而12周时，两组差异无统计学意义。结论有氧运动疗法可显著改善AD患者认知功能和精神神经症状，但对日常生活活动能力无影响；短期内高强度有氧运动较中等强度可能获益更多，长期则中等强度有氧运动与高强度的获益相似。
목적탐토중고강도유양운동요법대아이자해묵병(AD)환자적간예작용。방법장52례AD환자분위중등강도유양운동(중등강도)조(13례)、고강도유양운동(고강도)조(13례)화대조조(26례)。소유입조환자균안AD상규치료，중등강도조화고강도조분별접수강도위50%화70%최대운동능력적유양운동훈련12주，매주3차。우치료전、치료후8화12주대3조환자진행AD상관량표(MMSE、ADCS-ADL、NPI、NPI-D화ADAS-cog)평개，동시진행체격검사、혈상규、혈생화상규등검사。결과중등강도조、고강도조유양운동능명현개선환자적인지능력화정신신경증상，여대조조비교차이유통계학의의(P<0.05)；중등강도조화고강도조유양운동대환자일상생활활동능력무유익영향。제8주，고강도조MMSE화NPI평분교중등강도조개선경다(P<0.05)；이12주시，량조차이무통계학의의。결론유양운동요법가현저개선AD환자인지공능화정신신경증상，단대일상생활활동능력무영향；단기내고강도유양운동교중등강도가능획익경다，장기칙중등강도유양운동여고강도적획익상사。
Aim To evaluate the clinical efifcacy of aerobic exercises training of different intensities in patients with Alzheimer’s disease.Methods 52 patients with mild to moderate Alzheimer’s disease were randomly allocated into 3 groups. Two exercise groups were treated with aerobic exercises training at 50%or 70% of maximal intensity for 12 weeks, respectively.The efifcacy of aerobic exercises was evaluated by MMSE, ADCS-ADL, NPI, NPI-D, and ADAS-cog at baseline, the end of 8 weeks and the end of 12 weeks. Results Patients of the exercise groups got statistically signiifcant improvement in MMSE, NPI, NPI-D and ADAS-cog Tests (P<0.05). However, aerobic exercises did not improve the ADCS-ADL (P>0.05). Patients with 70% of maximal intensity exercise got a better improvement of MMSE and NPI than the patients with 50% of maximal intensity exercise (P<0.05) at the end of 8 weeks. However, 50% and 70% of maximal intensity provide similar effects at the end of 12 weeks.Conclusion Aerobic exercises can improve the cognitive and functional symptoms of AD patients, with acceptable safety and tolerance. Long term aerobic exercises with different intensity may provide similar beneift.