CAJ | 학술논문

目的：脑曲霉菌病的发病率日益增多，治疗药物有限，病死率很高。总结成功救治1例脑曲霉菌病患者的经验。方法立体定向下行脑穿刺活检术，脑组织病理活检结果明确诊断。治疗采用联合抗真菌治疗，伏立康唑0．2 g，2／d，静脉滴注，疗程70 d；间断小剂量鞘内注射两性霉素B，剂量0．1 mg，1／周。结果复查头颅磁共振，与初起病时比较病变明显吸收，临床症状好转。随访3年无复发。结论小剂量两性霉素B鞘内注射联合静脉滴注伏立康唑治疗脑曲霉菌病有较好疗效，无明显不良反应。
목적：뇌곡매균병적발병솔일익증다，치료약물유한，병사솔흔고。총결성공구치1례뇌곡매균병환자적경험。방법입체정향하행뇌천자활검술，뇌조직병리활검결과명학진단。치료채용연합항진균치료，복립강서0．2 g，2／d，정맥적주，료정70 d；간단소제량초내주사량성매소B，제량0．1 mg，1／주。결과복사두로자공진，여초기병시비교병변명현흡수，림상증상호전。수방3년무복발。결론소제량량성매소B초내주사연합정맥적주복립강서치료뇌곡매균병유교호료효，무명현불량반응。
Objective Cerebral aspergillosis is increasing with more immunocompromised hosts.At present,the treatment of cerebral aspergillosis is limited,which has a high mortality rate.We treated of a cerebral aspergillosis patient successfully,and provided the clinical reference.Methods We reported a case of a cerebral aspergillosis who was diagnosed by brain biopsy.We therapy with in-travenous caspofungin by two 0.2 g dose/day for 70 days,and combined intermittent small doses of intrathecal injection of amphotericin B by dose of just 0.1 mg,1/week.Results A magnetic resonance imaging of the brain and a cranial CT scan were reviewed.Pathologi-cal changes were absorbed and clinical symptoms from the previous improved markedly.We reviewed follow-up of 3 years without recur-rence.Conclusion Therapy with intravenous caspofungin and combined intermittent small doses of intrathecal injection of amphotericin B has a effect therapy,and which has a low side effect.