CAJ | 학술논문

目的：探讨在男性2型糖尿病患者中胰岛素抵抗与前列腺特异性抗原（ prostate specific antigen，PSA）的相关性。方法男性2型糖尿病183例，检测空腹血糖（ FPG）、空腹胰岛素（ FINS）、糖化血红蛋白（ HbA1C）、血脂系列（ TC、TG、LDL、HDL）、游离前列腺特异性抗原（ fPSA）和总前列腺特异性抗原（ tPSA）浓度等相关临床指标，计算胰岛素抵抗指数（ HOMA-IR）、体质指数（BMI）。根据HOMA-IR分为胰岛素抵抗组（IR≥2．8）和非胰岛素抵抗组（IR＜2．8）；根据tPSA的中位数0．732μg／L，将患者分为tPSA≥0.732μg／L组和tPSA＜0.732μg／L组。结果胰岛素抵抗组（69例）患者的BMI明显高于非胰岛素抵抗组（114例）（P＜0．05），tPSA明显低于非胰岛素抵抗组（P＜0．05）。 tPSA≥0．732μg／L组（92例）的BMI、HOMA-IR均低于tPSA＜0．732μg／L组（91例）（均P＜0．05）。 tPSA与年龄、fPSA、LDL呈正相关（ r分别为0．345、0．865、0．200；均P＜0.05），与IR、BMI呈负相关（r分别为-0．151、-0．155；均P＜0．05）。结论胰岛素抵抗和肥胖是导致PSA下降的因素。
목적：탐토재남성2형당뇨병환자중이도소저항여전렬선특이성항원（ prostate specific antigen，PSA）적상관성。방법남성2형당뇨병183례，검측공복혈당（ FPG）、공복이도소（ FINS）、당화혈홍단백（ HbA1C）、혈지계렬（ TC、TG、LDL、HDL）、유리전렬선특이성항원（ fPSA）화총전렬선특이성항원（ tPSA）농도등상관림상지표，계산이도소저항지수（ HOMA-IR）、체질지수（BMI）。근거HOMA-IR분위이도소저항조（IR≥2．8）화비이도소저항조（IR＜2．8）；근거tPSA적중위수0．732μg／L，장환자분위tPSA≥0.732μg／L조화tPSA＜0.732μg／L조。결과이도소저항조（69례）환자적BMI명현고우비이도소저항조（114례）（P＜0．05），tPSA명현저우비이도소저항조（P＜0．05）。 tPSA≥0．732μg／L조（92례）적BMI、HOMA-IR균저우tPSA＜0．732μg／L조（91례）（균P＜0．05）。 tPSA여년령、fPSA、LDL정정상관（ r분별위0．345、0．865、0．200；균P＜0.05），여IR、BMI정부상관（r분별위-0．151、-0．155；균P＜0．05）。결론이도소저항화비반시도치PSA하강적인소。
Objective To evaluate the relationship between insulin resistance and serum prostat specific antigen( PSA) levels in male patients with type 2 diabetics.Methods Totally 183 male patients with type 2 diabetics were included in this study.Biochemi-cal analyses including fasting plasma glucose(FPG),serum fasting levels of insulin(FINS),HbA1C,lipid,free prostate specific antigen ( fPSA) and total prostate specific antigen ( tPSA) were performed.Insulin resistance index( HOMA-IR) and body mass index ( BMI) were calculated.Based on HOMA-IR,patients were divided into insulin resistant group (IR>2.8) and non-insulin resistant group (IR<2.8) .Based on median of tPSA,patients were divided into group of tPSA≥0.732μg/L and group of tPSA<0.732μg/L.Results BMI was more increased in insulin resistant group (69 cases) compared with non-insulin resistant group (114 cases) (P<0.05).tP-SA was more increased in non-insulin resistant group compared with insulin resistant group(P<0.05).BMI and HOMA-IR were more increased in group of tPSA<0.732 μg/L (91 cases) compared with group of tPSA≥0.732μg/L (92 cases) (both P<0.05).tPSA was positively correlated with age,fPSA and LDL (r=0.345,0.865,0.200;all P<0.05),and negatively correlated with IR and BMI (r=-0.151,-0.155;both P<0.05).Conclusion Insulin resistance and obesity play roles in the PSA decreasing.