CAJ | 학술논문

目的：分析消化道肿瘤患者内源性促红细胞生成素水平及贫血状态,探讨使用重组人促红细胞生成素治疗消化道肿瘤相关性贫血的方案.方法内源性促红细胞生成素采用Elisa检测,血红蛋白采用常规检测.消化道肿瘤非贫血患者为对照组,消化道肿瘤贫血患者组为观察组.结果统计发现男女之间的贫血率没有差异,消化道肿瘤相关性贫血患者占38.95%,其中以胃癌居首,占42.2%,食管鳞癌最低,占35.6%.消化道肿瘤患者在化疗前贫血比非贫血患者EPO高而Hb低,两者存在逆相关关系,化疗后贫血患者Hb继续降低,EPO上升；而在化疗后非贫血患者中出现的26例贫血患者,其中16例出现EPO急剧上升,10例EPO几乎不变,EPO存在极显著差异,具有统计学意义,而Hb没有明显的差异.结论消化道肿瘤相关性贫血发生率较高,在临床治疗中要密切关注.
목적：분석소화도종류환자내원성촉홍세포생성소수평급빈혈상태,탐토사용중조인촉홍세포생성소치료소화도종류상관성빈혈적방안.방법내원성촉홍세포생성소채용Elisa검측,혈홍단백채용상규검측.소화도종류비빈혈환자위대조조,소화도종류빈혈환자조위관찰조.결과통계발현남녀지간적빈혈솔몰유차이,소화도종류상관성빈혈환자점38.95%,기중이위암거수,점42.2%,식관린암최저,점35.6%.소화도종류환자재화료전빈혈비비빈혈환자EPO고이Hb저,량자존재역상관관계,화료후빈혈환자Hb계속강저,EPO상승；이재화료후비빈혈환자중출현적26례빈혈환자,기중16례출현EPO급극상승,10례EPO궤호불변,EPO존재겁현저차이,구유통계학의의,이Hb몰유명현적차이.결론소화도종류상관성빈혈발생솔교고,재림상치료중요밀절관주.
Objective To analyze the endogenous erythropoietin(EPO) level and the anemia in patients with gastrointestinal tumors and study the therapeutic regimen with the recombinant human EPO ( rhEPO) for the treatment of gastrointestinal cancer-related anemia. Methods The endogenous EPO was detected with Elisa,and hemoglobin( Hb) was measured with the conventional method. Results The results revealed that there was no difference in the anemia rate between females and males,patients with gastrointestinal cancer accounted for 38. 95%,of which gastric cancer ranked the first, accounting for 42. 2%, and that of esophageal cancer-related anemia was the lowest, accounting for 35. 6%. The EPO level of patients with gastrointestinal cancer-related anemia was higher than that of non-anemia patients before the chemotherapy, but the Hb level was lower, presenting a inverse linear relation between the both;the Hb level of patients with the anemia dropped further and the EPO level increased after the chemotherapy. In the patients with gastrointestinal cancer but without anemia, 26 cases of them turned up anemia after the chemotherapy,16 cases of them showed a sharp increase in the EPO level,and 10 cases of them did not show an obvious difference in the EPO level, suggesting that there was a significant difference in EPO and no significant difference in Hb. Conclusion The incidence of gastrointestinal cancer-related anemia is high and a close attention should be paid to it in clinic.