CAJ | 학술논문

目的：探讨颈动脉粥样硬化斑块和同型半胱氨酸的相关性，为临床缺血性脑血管病防治方案的制定提供理论依据。方法选取我院收治的缺血性脑血管病患者126例，根据患者颈动脉彩色超声多普勒检查的结果，颈动脉稳定性斑块71例患者为A组，颈动脉不稳定性斑块的55例患者为B组。采集2组患者外周静脉血检测同型半胱氨酸水平并进行对比。结果2组患者三酰甘油、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平对比，差异均无统计学意义（P＞0．05）；A组和B组患者的同型半胱氨酸水平分别为（19．52±5．71）、（33．61±6．51）μmol/L，2组比较差异有统计学意义（ P＜0．05）。结论检测缺血性脑血管病动脉粥样硬化斑块患者同型半胱氨酸水平，有助于评估患者斑块的稳定性，指导临床的诊疗，预防急性脑血管事件的发生。
목적：탐토경동맥죽양경화반괴화동형반광안산적상관성，위림상결혈성뇌혈관병방치방안적제정제공이론의거。방법선취아원수치적결혈성뇌혈관병환자126례，근거환자경동맥채색초성다보륵검사적결과，경동맥은정성반괴71례환자위A조，경동맥불은정성반괴적55례환자위B조。채집2조환자외주정맥혈검측동형반광안산수평병진행대비。결과2조환자삼선감유、총담고순、저밀도지단백담고순화고밀도지단백담고순수평대비，차이균무통계학의의（P＞0．05）；A조화B조환자적동형반광안산수평분별위（19．52±5．71）、（33．61±6．51）μmol/L，2조비교차이유통계학의의（ P＜0．05）。결론검측결혈성뇌혈관병동맥죽양경화반괴환자동형반광안산수평，유조우평고환자반괴적은정성，지도림상적진료，예방급성뇌혈관사건적발생。
Objective To investigate the relationship between carotid atherosclerosis plaque and homocysteine, so as to pro-vide theoretical evidence for the development of prevention and treatment protocol in patients with clinical ischemic cerebrovascular dis-ease.Methods One hundred and twenty-six cases of ischemic cerebrovascular disease admitted into our hospital were selected as our study subjects.In accordance with the results of carotid artery color Doppler ultrasound detection, 71 cases of stable carotid plaques were designated as group A, and 55 cases of unstable carotid plaques were designated as group B.Peripheral venous blood from the pa-tients of both groups were collected for the detection of homocysteine levels and the results of detection were compared between the 2 groups.Results There were no statistical differences in the levels of triglyceride, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol in the patients of both groups, when comparisons were made between them ( P >0.05) .The homocysteine level in the patients of group A was (19.52 ±5.71) μmol/L, and the homocysteine level in the patients of group B was (33.61 ±6.51) μmol/L.As seen from above, the homocysteine level in the patients of group B was significantly higher than that of the patients in group A (P <0.05).Conclusion Detection of homocysteine levels in the patients with the formation of atherosclerosis plaque in ischemic cerebrovascular disease was helpful to the evaluation of plaque stability, the diagnosis and treatment of the disease, and the prevention of the occurrence of acute cerebrovascular events as well.