CAJ | 학술논문

细胞自噬是普遍存在于生物体内对抗外界压力而实现自我保护的一种机制，细胞自噬的功能状态异常（细胞自噬过度或者细胞自噬不足）可导致一系列疾病的产生。正常情况下，运动可以诱导机体多种组织细胞自噬的激活，心肌细胞的自噬激活对于维持心肌自身功能有着重要作用。本研究中，我们发现短期运动在导致细胞凋亡的同时可以激活心肌细胞的自噬，长期运动可以降低心肌细胞凋亡，增强其自噬的激活；同时，短期运动与长期运动均能提高抗氧化因子N RF-2的表达以加强心肌的保护功能；电镜结果证实长期运动可以提高心肌线粒体质量从而进一步实现心肌保护。
세포자서시보편존재우생물체내대항외계압력이실현자아보호적일충궤제，세포자서적공능상태이상（세포자서과도혹자세포자서불족）가도치일계렬질병적산생。정상정황하，운동가이유도궤체다충조직세포자서적격활，심기세포적자서격활대우유지심기자신공능유착중요작용。본연구중，아문발현단기운동재도치세포조망적동시가이격활심기세포적자서，장기운동가이강저심기세포조망，증강기자서적격활；동시，단기운동여장기운동균능제고항양화인자N RF-2적표체이가강심기적보호공능；전경결과증실장기운동가이제고심기선립체질량종이진일보실현심기보호。
Autophagy generally exists in organisms as a protective mechanism against external pressure .The dysfunction of autophagy such as excessive or insufficient autophagy can lead to many kinds of diseases .Exercise can induce the body to produce autophagy activation in a variety of tissues .Similarly ,under normal circumstances ,the activation of autophagy in cardiomyocytes can provide the maintenance of myocardial function .The present study showed that short-term exercise could result in the activation of both autophagy and apoptosis in myocardial cells .In contrast ,long-term exercise training could reduce the apoptosis of myocardial cells and increase the activation of autophagy .Meanwhile ,long-term exercise training could enhance the expression of antioxidant factors such as NRF-2 for strengthening the protection function to myocardial cells .Furthermore ,the results of electron microscope demonstrated that long -term exercise could improve the quality of mitochondria in myocardial cells ,thus executing the protective function on myocardial cells .