CAJ | 학술논문

本试验主要研究舒巴坦匹酯在肉鸡体内的药物动力学特征和生物利用度，以期为兽医临床用药提供依据。将20羽成年三黄肉鸡随机分成两组，采用单一两期交叉试验设计分别舒巴坦钠静注、舒巴坦匹酯口灌给药，利用高效液相色谱法测定血浆中药物浓度。静脉注射舒巴坦钠（舒巴坦3．75 mg／kg．B．W）后，主要药物动力学参数：t1／2α为0．090±0．001 h，t1／2β为0．919±0．011 h，AUC为6．137±0．376μg · h／mL， CLb为0．611±0．051 L／h／kg。舒巴坦匹酯口灌给药后（舒巴坦3．75 mg／kg．B．W），舒巴坦匹酯主要药动学参数：t1／2ka为0．087±0．007 h，t1／2β为2．044±0．165 h，AUC为4．109±0．364μg·h／mL，Tmax为0．412±0．039 h，Cmax为1．212±0．092μg／mL。肉鸡口灌舒巴坦匹酯后，吸收迅速，分布较快，消除也较快，舒巴坦匹酯的F为66．96％±5．95％。
본시험주요연구서파탄필지재육계체내적약물동역학특정화생물이용도，이기위수의림상용약제공의거。장20우성년삼황육계수궤분성량조，채용단일량기교차시험설계분별서파탄납정주、서파탄필지구관급약，이용고효액상색보법측정혈장중약물농도。정맥주사서파탄납（서파탄3．75 mg／kg．B．W）후，주요약물동역학삼수：t1／2α위0．090±0．001 h，t1／2β위0．919±0．011 h，AUC위6．137±0．376μg · h／mL， CLb위0．611±0．051 L／h／kg。서파탄필지구관급약후（서파탄3．75 mg／kg．B．W），서파탄필지주요약동학삼수：t1／2ka위0．087±0．007 h，t1／2β위2．044±0．165 h，AUC위4．109±0．364μg·h／mL，Tmax위0．412±0．039 h，Cmax위1．212±0．092μg／mL。육계구관서파탄필지후，흡수신속，분포교쾌，소제야교쾌，서파탄필지적F위66．96％±5．95％。
The experiment mainly studied pharmacokinetics and bioavailability of sulbactam pivoxyl in broilers, providing the basis for clinical uses of veterinary drugs. 20 feather adult Sanhuang broilers were randomly divided into two groups, using a single two-period crossover experiment design, respectively by intravenous injection of sulbactam and oral administration of sulbactam pivoxyl, and adopting high performance liquid chromatography to determine concentrations of this drug in plasma. After the intravenous injection of sulbactam sodium ( sulbactam 3.75 mg/kg.B.W),the main pharmacokinetic parameters were as follows: t1/2αwas 0.090 ± 0.001 h, t1/2β was 0.919 ± 0.011 h, AUC was 6.137 ± 0.376 μg · h/mL, CLb was 0.611 ± 0.051 L/h/kg. And after sulbactam pivoxyl was orally administrated ( sulbactam 3 . 7 5 mg / kg . B . W ) , the major pharmacokinetics parameters of this drug were as follows:t1/2ka was 0.087 ± 0.007 h, t1/2βwas 2.044 ± 0.165 h, AUC was 4.109 ± 0.364μg · h/mL, Tmax was 0.412 ± 0.039 h, Cmax was 1.212 ± 0.092 μg/mL. After oral administration of sulbactam pivoxyl, this drug was absorbed quickly, distributed faster, and also eliminated faster, and the bioavailability of sulbactam pivoxyl was 66.96% ± 5.95%.