天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2014年
10期
1048-1050
,共3页
肿瘤干细胞%微RNAs%肿瘤标记,生物学%综述
腫瘤榦細胞%微RNAs%腫瘤標記,生物學%綜述
종류간세포%미RNAs%종류표기,생물학%종술
neoplastic stem cells%microRNAs%tumor markers,biological%review
肿瘤干细胞（CSCs）理论为肿瘤的研究开辟了一个新的方向，CSCs学说认为肿瘤细胞具有异质性，肿瘤中存在干细胞样细胞，该群细胞是一种增殖失控、可形成肿瘤的细胞，只占肿瘤细胞很少部分，具有干细胞特性，是形成不同分化程度肿瘤细胞和肿瘤增长、复发及转移的根源。微小RNA（miRNA）是广泛存在的非编码小RNA，调节着人类1/3的基因，越来越多的证据显示miRNA在肿瘤的发生发展中起着重要的作用，作为重要的转录后调控因子，广泛参与肿瘤相关基因调控的生物程序，使不同类型的肿瘤表现出特异的miRNA表达谱。近年来，CSCs的miRNA研究日益成为热点，已经发现多种CSCs中存在特异性表达的miRNA，对CSCs的生物学行为有了更进一步的认识，发现肿瘤患者血浆中表达某些特异的miRNA，这些miRNA可以作为肿瘤的标志物对患者的病情及预后进行预测和判断。本文就近来CSCs中miRNA研究进展及miRNA作为肿瘤标志物研究进展进行综述。
腫瘤榦細胞（CSCs）理論為腫瘤的研究開闢瞭一箇新的方嚮，CSCs學說認為腫瘤細胞具有異質性，腫瘤中存在榦細胞樣細胞，該群細胞是一種增殖失控、可形成腫瘤的細胞，隻佔腫瘤細胞很少部分，具有榦細胞特性，是形成不同分化程度腫瘤細胞和腫瘤增長、複髮及轉移的根源。微小RNA（miRNA）是廣汎存在的非編碼小RNA，調節著人類1/3的基因，越來越多的證據顯示miRNA在腫瘤的髮生髮展中起著重要的作用，作為重要的轉錄後調控因子，廣汎參與腫瘤相關基因調控的生物程序，使不同類型的腫瘤錶現齣特異的miRNA錶達譜。近年來，CSCs的miRNA研究日益成為熱點，已經髮現多種CSCs中存在特異性錶達的miRNA，對CSCs的生物學行為有瞭更進一步的認識，髮現腫瘤患者血漿中錶達某些特異的miRNA，這些miRNA可以作為腫瘤的標誌物對患者的病情及預後進行預測和判斷。本文就近來CSCs中miRNA研究進展及miRNA作為腫瘤標誌物研究進展進行綜述。
종류간세포（CSCs）이론위종류적연구개벽료일개신적방향，CSCs학설인위종류세포구유이질성，종류중존재간세포양세포，해군세포시일충증식실공、가형성종류적세포，지점종류세포흔소부분，구유간세포특성，시형성불동분화정도종류세포화종류증장、복발급전이적근원。미소RNA（miRNA）시엄범존재적비편마소RNA，조절착인류1/3적기인，월래월다적증거현시miRNA재종류적발생발전중기착중요적작용，작위중요적전록후조공인자，엄범삼여종류상관기인조공적생물정서，사불동류형적종류표현출특이적miRNA표체보。근년래，CSCs적miRNA연구일익성위열점，이경발현다충CSCs중존재특이성표체적miRNA，대CSCs적생물학행위유료경진일보적인식，발현종류환자혈장중표체모사특이적miRNA，저사miRNA가이작위종류적표지물대환자적병정급예후진행예측화판단。본문취근래CSCs중miRNA연구진전급miRNA작위종류표지물연구진전진행종술。
The theory of cancer stem cells (CSCs) provides a new perspective for the study of cancer. CSCs doctrine presumes that tumor cells are heterogeneity, and there are cancer stem-like cells in tumors, whose proliferation is uncon-trolled. The cancer stem-like cells could form tumors from only few cells, who only account for a very small part of all the tu-mor cells. These cells with stem cells characteristics could form different extend of differentiation of tumor cells and work as source of tumor growth, recurrence and metastasis. miRNAs are widely-existed non-coding small RNAs, which regulate 1/3 of all human genes and participate in a series of essential processes of life. More and more evidences indicate that miRNAs contribute significantly to cancer generation and development. They may exhibit oncogenic activity and act as tumor suppres-sors. As one of the post-transcriptional controlling factors, they regulate biological processes of tumor related genes exten-sively and specific miRNAs expression profiles were shown in different cancers. The research of miRNA about CSCs has be-come very hot. Some studies have confirmed that miRNAs play a very important role in a variety of CSCs, which act as a new target for tumor therapy. Researchers have found that some specific miRNAs express in plasma of cancer patients, which can be used as tumor markers to assist diagnosis and prognosis. This review focused on current progress of research in function of miRNAs in CSCs and its role as tumor markers.
