CAJ | 학술논문

目的：研究树突状细胞（DC）在声带息肉、喉黏膜白斑及声门型喉鳞癌组织中的表达差异。方法采用免疫组化方法检测20例声带息肉组织、47例喉黏膜白斑组织、45例声门型喉鳞癌组织及20例正常喉黏膜组织中S-100+DC及CD83+DC的浸润情况。结果声带息肉组、喉白斑组、声门型喉鳞癌组的S-100及CD83+DC数较正常喉黏膜组明显增多（P<0.05）；声带息肉组S-100及CD83+DC数比喉白斑组明显增多，声带息肉组及喉白斑组S-100及CD83+DC数较声门型喉鳞癌组有所增加；在喉黏膜白斑组织中重度不典型增生组S-100及CD83+DC数明显高于轻、中度不典型增生组（P<0.05）；高、中分化声门型喉鳞癌组S-100及CD83+DC数高于低分化组（P<0.05）。结论声带息肉、喉黏膜白斑及声门型喉鳞癌均存在免疫活动异常，DC的变化在喉癌发生发展过程中发挥重要作用。
목적：연구수돌상세포（DC）재성대식육、후점막백반급성문형후린암조직중적표체차이。방법채용면역조화방법검측20례성대식육조직、47례후점막백반조직、45례성문형후린암조직급20례정상후점막조직중S-100+DC급CD83+DC적침윤정황。결과성대식육조、후백반조、성문형후린암조적S-100급CD83+DC수교정상후점막조명현증다（P<0.05）；성대식육조S-100급CD83+DC수비후백반조명현증다，성대식육조급후백반조S-100급CD83+DC수교성문형후린암조유소증가；재후점막백반조직중중도불전형증생조S-100급CD83+DC수명현고우경、중도불전형증생조（P<0.05）；고、중분화성문형후린암조S-100급CD83+DC수고우저분화조（P<0.05）。결론성대식육、후점막백반급성문형후린암균존재면역활동이상，DC적변화재후암발생발전과정중발휘중요작용。
Objective To investigate the infiltration of dendritic cell (DC) in Vocal cord polyp, laryngeal leukopla-kia and glottic squamous cell carcinoma,and to observe laryngeal mucosal lesions of the state of the immune microenviron-ment, and to research significance of DC on the development of glottic squamous cell carcinoma. Methods The infiltration of S-100+and CD83+DC in 20 cases of Vocal cord polyp, 47 cases of laryngeal leukoplakia, 45 cases of glottic squamous cell carcinoma tumor and 20 cases of laryngeal normal mucosa were examined using immunohistochemistry. Results The num-ber of S-100+and CD83+DC were significantly higher in glottic squamous cell carcinoma, laryngeal leukoplakia and vocal cord polyp than that in laryngeal normal mucosa (P<0.05). The number of S-100+and CD83+DC were higher in laryngeal leukoplakia than that in glottic squamous cell carcinoma (P<0.05). The number of S-100+and CD83+DC in mild dysplasia and moderate dysplasia were less than that in severe atypical hyperplasia (P<0.01). In glottic squamous cell carcinoma, S-100+ and CD83+DC with poor-differentiated was significantly less than that with well-differentiated (P < 0.01). Conclu-sion Changes in the number of dendritic cell was found in vocal cord polyp, laryngeal leukoplakia and glottic squamous cell carcinoma, which indicated that there were an abnormal immune status. Changing of dendritic cell in laryngeal mucosa plays an important role in laryngeal cancer development.