CAJ | 학술논문

目的：观察5-氨基酮戊酸光动力疗法（5-ALA-PDT）治疗皮肤癌前病变和浅表皮肤肿瘤的疗效。方法：对7例日光性角化病、5例基底细胞癌、2例鲍温病、1例乳房外paget病患者进行5-氨基酮戊酸光动力疗法（5-ALA-PDT）治疗。结果：随访6个月，7例日光性角化病患者中，6例患者皮损获得完全缓解，1例部分缓解；5例基底细胞癌患者中，2例完全缓解，2例部分缓解，1例无反应。2例鲍温病患者均获得完全缓解；1例乳房外paget病患者部分缓解。结论：使用5-ALA-PDT治疗皮肤肿瘤，疗效好、痛苦小、美容效果满意，特别适合一般情况差，难以耐受手术的特殊患者，可在临床工作中进一步推广。
목적：관찰5-안기동무산광동력요법（5-ALA-PDT）치료피부암전병변화천표피부종류적료효。방법：대7례일광성각화병、5례기저세포암、2례포온병、1례유방외paget병환자진행5-안기동무산광동력요법（5-ALA-PDT）치료。결과：수방6개월，7례일광성각화병환자중，6례환자피손획득완전완해，1례부분완해；5례기저세포암환자중，2례완전완해，2례부분완해，1례무반응。2례포온병환자균획득완전완해；1례유방외paget병환자부분완해。결론：사용5-ALA-PDT치료피부종류，료효호、통고소、미용효과만의，특별괄합일반정황차，난이내수수술적특수환자，가재림상공작중진일보추엄。
Objective:To investigate the effects of 5-aminolaevulinic acid-photodynamic therapy( 5-ALA-PDT)on precancerous changes and superficial skin cancer. Methods:Seven patients with actinic keratosis( AK),5 patients with basal cell cancer( BCC),2 patients with Bowen's disease and 1 patient with extramammary Pagetˊs dis-ease were given topical 5-ALA followed by PDT. Results:After followed-up for 6 months,7 patients with AK,2 pa-tients with BCC,2 patients with Bowen's disease achieved complete remission( CR),1 patient with AK,2 patients with BCC,1 patient with extramammary Pagetˊs disease achieved partial remission( PR). No response was observed in BCC patients. Conclusion:Topical 5-ALA-PDT is a simple,effective and new treatment with excellent cosmetic re-sults for precancerous changes and superficial skin cancer.