CAJ | 학술논문

目的：在胃肠道肿瘤患者应用奥沙利铂+亚叶酸钙+氟尿嘧啶（ FOLFOX方案）化疗后，观察延长奥沙利铂输注时间对其外周神经毒性的预防作用。方法：98例肿瘤患者随机分为三组，A组在使用奥沙利铂时将滴注时间延长至6小时；B组延长至4小时；C组奥沙利铂滴注时间为2小时。在化疗6周期及化疗12周期后分别比较三组神经毒性的总发生率及外周神经毒性级别。结果：6周期化疗后A组神经毒性的总发生率明显低于C组（P=0.0003）；B组神经毒性的总发生率亦低于C组（P=0.034）；A组神经毒性发生率低于B组（P=0.027），均具有统计学意义。12周期化疗后A组神经毒性的总发生率明显低于C组（P=0.002）；B组神经毒性的总发生率亦低于C组（P=0.025）；而A组和B组之间比较无统计学差异（P=0.371）。结论：使用奥沙利铂时将滴注时间延长至4-6小时可以有效减少神经毒性发生。
목적：재위장도종류환자응용오사리박+아협산개+불뇨밀정（ FOLFOX방안）화료후，관찰연장오사리박수주시간대기외주신경독성적예방작용。방법：98례종류환자수궤분위삼조，A조재사용오사리박시장적주시간연장지6소시；B조연장지4소시；C조오사리박적주시간위2소시。재화료6주기급화료12주기후분별비교삼조신경독성적총발생솔급외주신경독성급별。결과：6주기화료후A조신경독성적총발생솔명현저우C조（P=0.0003）；B조신경독성적총발생솔역저우C조（P=0.034）；A조신경독성발생솔저우B조（P=0.027），균구유통계학의의。12주기화료후A조신경독성적총발생솔명현저우C조（P=0.002）；B조신경독성적총발생솔역저우C조（P=0.025）；이A조화B조지간비교무통계학차이（P=0.371）。결론：사용오사리박시장적주시간연장지4-6소시가이유효감소신경독성발생。
Objective:To evaluate the preventive effect to oxaliplatin neurotoxicity by extending the infusion time of using oxaliplatin in patients with gastrointestinal tumor after chemotherapy with FOLFOX regimen. Methods:All 98 cancer patients were randomized into three groups. Infusion time of group A was extended to 6 hours when using oxali-platin,Infusion time of group B and group C was 4 hours and 2 hours when using oxaliplatin. Then evaluated the inci-dence and level of oxaliplatin neurotoxicity after 6 cycles and 12 cycles of chemotherapy. Results:After 6 cycles of chemotherapy,the incidence of oxaliplatin neurotoxicity of group A was lower than that of group C(P=0. 0003),the incidence of group B was lower than that of group C as well(P=0. 034),and the incidence of group A was lower than that of group B(P=0. 027). After 12 cycles of chemotherapy,the incidence of group A was lower than that of group C(P=0. 002),the incidence of group B was lower than that of group C as well(P=0. 025),and the inci-dence had no statistical singnificance between the group A and B(P=0. 371). Conclusion:Extending the infusion time to 4-6 hours when using oxaliplatin can reduce the incidence of oxaliplatin neurotoxicity.