CAJ | 학술논문

目的：探讨Ubc9在人肺癌组织中的表达及临床意义。方法：应用免疫组织化学法和实时荧光定量PCR（ real time quantitative PCR，RT-qPCR）法检测143例肺癌组织及同源非癌变组织中Ubc9的表达情况，并对临床病理资料进行分析。结果：与癌旁组织相比，Ubc9在肺癌组织中呈高表达（ P<0.05），Ubc9的表达与年龄、淋巴结转移、TNM分期及预后密切相关，有统计学意义（ P<0.05）；而与性别、病理学类型、组织分化程度无关。结论：小细胞肺癌、肺鳞癌和肺腺癌中均有Ubc9阳性表达，均高于正常的肺组织，并且与肺癌淋巴结转移程度相关，提示Ubc9可能与肺癌细胞的转移特性有关。
목적：탐토Ubc9재인폐암조직중적표체급림상의의。방법：응용면역조직화학법화실시형광정량PCR（ real time quantitative PCR，RT-qPCR）법검측143례폐암조직급동원비암변조직중Ubc9적표체정황，병대림상병리자료진행분석。결과：여암방조직상비，Ubc9재폐암조직중정고표체（ P<0.05），Ubc9적표체여년령、림파결전이、TNM분기급예후밀절상관，유통계학의의（ P<0.05）；이여성별、병이학류형、조직분화정도무관。결론：소세포폐암、폐린암화폐선암중균유Ubc9양성표체，균고우정상적폐조직，병차여폐암림파결전이정도상관，제시Ubc9가능여폐암세포적전이특성유관。
Objective:To investigate the expressions and clinical significance of Ubc9 in human lung cancer and its prognostic significance. Methods:The expression of Ubc9 in 143 lung cancer specimens and adjacent normal tis-sues were detected by immunohistochemical( IHC)and real time quantitative PCR method. The relationship between the Ubc9 expression and pathological data,prognostic factors were analyzed. Results:Compared with adjacent normal tissues,the expression of Ubc9 mRNA in cancerous tissues was higher(P<0. 05). The expression of Ubc9 was statis-tically significantly correlated with age,lymph nodes metastasis,clinical stage and prognosis(P<0. 05),but was not correlated with sex,histological type,differential(P>0. 05). Conclusion:The high expressions of Ubc9 in lung canc-er was related to lymph nodes metastasis,and may be associated with the metastasis of lung cancer.