CAJ | 학술논문

目的：探讨胸苷激酶1（TK1）对常见恶性肿瘤诊断的临床应用。方法采用酶免疫点印迹化学发光法检测444例肿瘤患者和161例健康体检者（对照组）血清中T K1水平。结果与对照组比较，肺癌、消化道肿瘤、乳腺癌患者血清 T K1水平均显明显升高（P＜0．05）。肺癌、食管癌、结肠癌、直肠癌、乳腺癌、宫颈癌、卵巢癌患者TK1检测阳性率，分别为52．0％、59．6％、62．9％、60．0％、62．1％、32．3％、21．4％、11．0％。与对照组（T K1检测阳性率为0．0％）比较，肺癌、消化道肿瘤、乳腺癌 T K1检测阳性率明显升高（P＜0．01）。结论血清TK1检测在常见恶性肿瘤的辅助诊断上是一个有价值的指标。
목적：탐토흉감격매1（TK1）대상견악성종류진단적림상응용。방법채용매면역점인적화학발광법검측444례종류환자화161례건강체검자（대조조）혈청중T K1수평。결과여대조조비교，폐암、소화도종류、유선암환자혈청 T K1수평균현명현승고（P＜0．05）。폐암、식관암、결장암、직장암、유선암、궁경암、란소암환자TK1검측양성솔，분별위52．0％、59．6％、62．9％、60．0％、62．1％、32．3％、21．4％、11．0％。여대조조（T K1검측양성솔위0．0％）비교，폐암、소화도종류、유선암 T K1검측양성솔명현승고（P＜0．01）。결론혈청TK1검측재상견악성종류적보조진단상시일개유개치적지표。
Objective To study the clinical application of thymidine kinase 1(TK1) in diagnosis of common malignant tumors . Methods The serum TK1 levels of 444 cancer patients and 161 healthy individual(control group) were tested by western blot-en-hanced chemiluminescence assay .Results Compared with control group ,the levels of TK1 in patients with lung cancer ,gastrointes-tinal cancer or breast cancer were significantly higher(P<0 .05) .The positive rates of TK1 in lung cancer ,esophageal cancer ,colon cancer ,colorectal cancer ,breast cancer ,cervical cancer and ovarian cancer were respectively 52 .0% ,59 .6% ,62 .9% ,60 .0% , 62 .1% ,32 .3% ,21 .4% and 11 .0% .Compared with control group(the positive rate of TK1 was 0 .0% ) ,the positive rate of TK1 in lung cancer ,gastrointestinal cancer or breast cancer were significantly higher(P<0 .01) .Conclusion The test of serum TK1 is a valuable marker in common malignant tumor auxiliary diagnosis .