CAJ | 학술논문

目的：探讨尿微量清蛋白（mALB）、α1-微球蛋白（α1-M ）和N-乙酰-β-D-氨基葡萄糖苷酶（NAG）检测在诊断肾脏早期损伤中的意义。方法以63例糖尿病患者（糖尿病组），58例高血压患者（高血压组）和64例健康体检者（对照组）为研究对象，采用免疫散射比浊法检测尿液中mALB、α1-M水平，采用终点比色法测尿液中NAG活性。结果糖尿病组和高血压组尿液中mALB、α1-M水平和NAG活性均高于对照组，差异有统计学意义（P＜0．05）。糖尿病组和高血压组尿液中mALB、α1-M水平和N A G活性的单项检测阳性率均低于50．0％，任意2项指标联合检测的阳性率均高于50．0％，3项指标联合检测的阳性率则高于70．0％。结论尿液中mALB、α1-M及NAG联合检测是诊断肾脏早期损伤的敏感指标。
목적：탐토뇨미량청단백（mALB）、α1-미구단백（α1-M ）화N-을선-β-D-안기포도당감매（NAG）검측재진단신장조기손상중적의의。방법이63례당뇨병환자（당뇨병조），58례고혈압환자（고혈압조）화64례건강체검자（대조조）위연구대상，채용면역산사비탁법검측뇨액중mALB、α1-M수평，채용종점비색법측뇨액중NAG활성。결과당뇨병조화고혈압조뇨액중mALB、α1-M수평화NAG활성균고우대조조，차이유통계학의의（P＜0．05）。당뇨병조화고혈압조뇨액중mALB、α1-M수평화N A G활성적단항검측양성솔균저우50．0％，임의2항지표연합검측적양성솔균고우50．0％，3항지표연합검측적양성솔칙고우70．0％。결론뇨액중mALB、α1-M급NAG연합검측시진단신장조기손상적민감지표。
Objective To explore the diagnosis value of joint detection of microalbumin(mALB) ,α1-Microglolin(α1-M ) and N-acety-β-D-glucosaminidase(NAG) in the diabetes and hypertension patients with early injury of kidney .Methods Sample were col-lected from July 2013 to January 2014 ,including 63 diabetic cases(diabetic group) ,58 patients with hypertension(hypertension group) and 64 health controls(control group) ,then the levels of urinary mALB ,α1-M were detected by immunoturbidimetry ,urina-ry NAG activity was assessed by endpoint colorimetric assay .Results The levels of urinary mALB ,α1-M and NAG in diabetic group and hypertension group were higher than those in control group(P<0 .05) .The positive rates of three indices single detected were less than 50 .0% ,the positive rates of any two indices joint detected were more than 50 .0% ,the positive rate of three indices joint detected was more than 70 .0% .Conclusion The method of urinary mALB ,α1-M and NAG joint detected is sensitive and reli-able for diagnosing of the early injury of kidney .