CAJ | 학술논문

目的：探讨糖化血红蛋白（HbA1c）、C反应蛋白（CRP）、白细胞介素6（IL-6）与缺血修饰清蛋白（IM A ）对糖尿病肾病早期诊断的价值。方法收集64例2型糖尿病患者的临床资料（单纯2型糖尿病患者34例，糖尿病肾病患者30例），检测各组患者血液中 HbA1c、h-CRP、IL-6和IM A水平，另选对照组40例，并进行对比分析。结果单纯2型糖尿病组 HbA1c、h-CRP、IL-6和IMA水平均明显高于对照组（P＜0．05），糖尿病肾病组 HbA1c、h-CRP、IL-6和IMA水平又明显高于单纯2型糖尿病组（P＜0．05）；HbA1c水平与h-CRP、IL-6、IMA水平呈正相关（P＜0．05）；HbA1c、h-CRP、IL-6和IMA项联合检测糖尿病肾病的阳性检出率明显高于单项指标（P＜0．05）。结论联合检测 HbA1c、h-CRP、IL-6和IMA水平有利于糖尿病肾病的早期检出。
목적：탐토당화혈홍단백（HbA1c）、C반응단백（CRP）、백세포개소6（IL-6）여결혈수식청단백（IM A ）대당뇨병신병조기진단적개치。방법수집64례2형당뇨병환자적림상자료（단순2형당뇨병환자34례，당뇨병신병환자30례），검측각조환자혈액중 HbA1c、h-CRP、IL-6화IM A수평，령선대조조40례，병진행대비분석。결과단순2형당뇨병조 HbA1c、h-CRP、IL-6화IMA수평균명현고우대조조（P＜0．05），당뇨병신병조 HbA1c、h-CRP、IL-6화IMA수평우명현고우단순2형당뇨병조（P＜0．05）；HbA1c수평여h-CRP、IL-6、IMA수평정정상관（P＜0．05）；HbA1c、h-CRP、IL-6화IMA항연합검측당뇨병신병적양성검출솔명현고우단항지표（P＜0．05）。결론연합검측 HbA1c、h-CRP、IL-6화IMA수평유리우당뇨병신병적조기검출。
Objective To explore the clinical value of glycosylated hemoglobin A1(HbA1c) ,C-reactive protein(CRP) ,interleu-kin-6(IL-6) and ischemia modified albumin(IMA) in patients with type 2 diabetes nephropathy .Methods 64 patients with type 2 diabetes mellitus were divided into simple diabetic mellitus group(34 patients) and diabetic nephropathy group(30 patients) .In ad-dition ,40 healthy subjects were chosen as control group .The levels of HbA1c ,CRP ,IL-6 and IMA were detected .Results The lev-els of HbA1c ,CRP ,IL-6 and IMA in simple diabetic mellitus group were all significantly higher than those in control group(P<0 .05) .The levels of HbA1c ,CRP ,IL-6 and IMA in diabetic nephropathy group were all significantly higher than those in simple di-abetic mellitus group(P<0 .05) .There were a positive correlations between the HbA1c level and the levels of CRP ,IL-6 ,IMA(P<0 .05) .The positive rate of combined detection of HbA1c ,CRP ,IL-6 and IMA was significantly higher than separate index detection (P<0 .05) .Conclusion The combined detection of HbA1c ,CRP ,IL-6 and IMA may be beneficial to the early diagnosis of diabetic nephropathy ,which will delay the progress of diabetic nephropathy .