CAJ | 학술논문

目的：观察帕诺洛司琼与利多卡因用于减轻罗库溴铵注射痛效果的比较。方法：200例需气管插管全身麻醉进行手术的患者，A S AⅠ～Ⅱ级，随机分为A、B、C和D组，每组各50例。给予静脉预处理液前关闭补液，A组静脉注射生理盐水10ml ，B组静脉注射帕诺洛司琼0．25mg ，C组注射利多卡因40mg ，D组注射帕洛诺司琼0．25mg＋利多卡因40mg ；1min后开放补液，予咪达唑仑0．1mg/kg ，待患者睫毛反射消失后，予罗库溴铵0．6mg/kg ，以4点评级来评价患者对罗库溴铵注射痛的反应并记录疼痛发生的频数。结果：D组1～3级的例数均显著低于A、B、C组，差异有统计学意义。结论：全麻诱导前予帕洛诺司琼联合利多卡因静脉预处理可有效减少罗库溴铵注射痛的发生。
목적：관찰파낙락사경여리다잡인용우감경라고추안주사통효과적비교。방법：200례수기관삽관전신마취진행수술적환자，A S AⅠ～Ⅱ급，수궤분위A、B、C화D조，매조각50례。급여정맥예처리액전관폐보액，A조정맥주사생리염수10ml ，B조정맥주사파낙락사경0．25mg ，C조주사리다잡인40mg ，D조주사파락낙사경0．25mg＋리다잡인40mg ；1min후개방보액，여미체서륜0．1mg/kg ，대환자첩모반사소실후，여라고추안0．6mg/kg ，이4점평급래평개환자대라고추안주사통적반응병기록동통발생적빈수。결과：D조1～3급적례수균현저저우A、B、C조，차이유통계학의의。결론：전마유도전여파락낙사경연합리다잡인정맥예처리가유효감소라고추안주사통적발생。
Objective:The aim of this study was to evaluate the efficacy of pretreatment with palonosetron and lido-caine on rocuronium injection associated pain .Methods:200 patients (ASAⅠ ~ Ⅱ) scheduled for gynecological laparos-copy under general anesthesia were randomized into 4 groups (n=50) .Control group (group A ,normal saline 10ml) , palonosetron group (group B ,palonosetron 0 .25mg) ,lidocaine group (group C ,lidocaine 40mg) ,palonosetron+ lido-caine group (group D ,palonosetron 0 .25mg+lidocaine 40mg) ,the pretreatment drugs were all diluted into 10ml in each group ,and injected after iv fluid stopped .One minutes later ,general anesthesia were induced with midazolam 0.1mg/kg ,and rocuronium 0 .6mg/kg were injected when patients loss of consciousness .Injection pain was graded using a 4-point scale ,and patients responses were recorded .Results:Grade 1~3 response in group D were significantly lower than group A ,group B and group C(P<0 .05) .Conclusion:Pretreatment with palonosetron combined with lidocaine can significantly reduce the incidence of rocuronium injection associated pain .