国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
19期
2611-2612
,共2页
刘付明军%邱振华%许军生%陈泽城
劉付明軍%邱振華%許軍生%陳澤城
류부명군%구진화%허군생%진택성
心肌酶谱%心肌肌钙蛋白I%新生儿缺氧缺血性脑病
心肌酶譜%心肌肌鈣蛋白I%新生兒缺氧缺血性腦病
심기매보%심기기개단백I%신생인결양결혈성뇌병
myocardial enzyme spectrum%cardiac troponin I%neonatal hypoxic ischemic encephalopathy
目的:探讨血清心肌酶谱及心肌肌钙蛋白I(cTnI)检测在新生儿缺氧缺血性脑病(HIE)中的诊断意义。方法收集65例HIE患儿(HIE组),采用日立7602生化仪检测血清心肌酶谱水平,采用化学发光法检测血清cTnI水平,并以68例健康新生儿为对照组,分析各组心肌酶谱及cTnI水平变化情况。结果 HIE组天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶MB同工酶(CK-MB)、乳酸脱氢酶(LDH)及α-羟丁酸脱氢酶(HBDH)的水平,分别为(98.9±9.6)U/L、(385.4±15.5)U/L、(89.3±9.6)U/L、(300.8±19.8)U/L 、(399.1±17.9)U/L ,均明显高于对照组(P<0.05)。 HIE组cTnI水平为(1.4±0.4)ng/mL ,高于对照组(P<0.05)。CK-MB检测新生儿HIE的灵敏度为88.6%,cTnI检测新生儿 HIE的特异性为86.3%。结论血清心肌酶谱及cTnI检测对新生儿HIE的诊断和治疗具有重要意义。
目的:探討血清心肌酶譜及心肌肌鈣蛋白I(cTnI)檢測在新生兒缺氧缺血性腦病(HIE)中的診斷意義。方法收集65例HIE患兒(HIE組),採用日立7602生化儀檢測血清心肌酶譜水平,採用化學髮光法檢測血清cTnI水平,併以68例健康新生兒為對照組,分析各組心肌酶譜及cTnI水平變化情況。結果 HIE組天門鼕氨痠氨基轉移酶(AST)、肌痠激酶(CK)、肌痠激酶MB同工酶(CK-MB)、乳痠脫氫酶(LDH)及α-羥丁痠脫氫酶(HBDH)的水平,分彆為(98.9±9.6)U/L、(385.4±15.5)U/L、(89.3±9.6)U/L、(300.8±19.8)U/L 、(399.1±17.9)U/L ,均明顯高于對照組(P<0.05)。 HIE組cTnI水平為(1.4±0.4)ng/mL ,高于對照組(P<0.05)。CK-MB檢測新生兒HIE的靈敏度為88.6%,cTnI檢測新生兒 HIE的特異性為86.3%。結論血清心肌酶譜及cTnI檢測對新生兒HIE的診斷和治療具有重要意義。
목적:탐토혈청심기매보급심기기개단백I(cTnI)검측재신생인결양결혈성뇌병(HIE)중적진단의의。방법수집65례HIE환인(HIE조),채용일립7602생화의검측혈청심기매보수평,채용화학발광법검측혈청cTnI수평,병이68례건강신생인위대조조,분석각조심기매보급cTnI수평변화정황。결과 HIE조천문동안산안기전이매(AST)、기산격매(CK)、기산격매MB동공매(CK-MB)、유산탈경매(LDH)급α-간정산탈경매(HBDH)적수평,분별위(98.9±9.6)U/L、(385.4±15.5)U/L、(89.3±9.6)U/L、(300.8±19.8)U/L 、(399.1±17.9)U/L ,균명현고우대조조(P<0.05)。 HIE조cTnI수평위(1.4±0.4)ng/mL ,고우대조조(P<0.05)。CK-MB검측신생인HIE적령민도위88.6%,cTnI검측신생인 HIE적특이성위86.3%。결론혈청심기매보급cTnI검측대신생인HIE적진단화치료구유중요의의。
Objective To discuss the value of analysis of serum myocardial enzyme spectrum and cardiac troponin I(cTnI) in neonatal hypoxic ischemic encephalopathy(HIE) .Methods Serum level of myocardial enzyme spectrum in each people was deter-mined with Hitachi 7602 ,Serum levels of cTnI was determined by chemoluminescence method .Serum levels of myocardial enzyme spectrum and cTnI were collect from 65 neonates with HIE(HIE group) and 68 cases of helthy volunteers(control group) .Results The levels of glutamic oxalacetic transaminase(AST) ,creatine kinase(CK) ,creatine kinase MB isoenzyme(CK-MB) ,lactic dehy-drogenase(LDH) and alpha-hydroxybutyric dehydrogenase(HBDH) in HIE group were(98 .9 ± 9 .6)U/L ,(385 .4 ± 15 .5)U/L , (89 .3 ± 9 .6)U/L ,(300 .8 ± 19 .8)U/L ,(399 .1 ± 17 .9)U/L ,which were higher than those in control group(P<0 .05) .The level of cTnI was(1 .4 ± 0 .4)ng/mL in HIE group ,which was higher than that in control group(P<0 .05) .CK-MB sensitivity was 88 .6% , cTnI speciality rate was 86 .3% .Conclusion The assay of myocardial enzyme spectrum and cTnI is significant in diagnosis of neo-natal HIE .