国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
19期
2595-2596
,共2页
结直肠癌%切除修复交叉互补基因1%基因多态性
結直腸癌%切除脩複交扠互補基因1%基因多態性
결직장암%절제수복교차호보기인1%기인다태성
colorectal cancer%excision repair cross-complementation gene 1%polymorphism
目的:分析结直肠癌患者切除修复交叉互补基因1(ERCC1)的基因多态性,以期能为结直肠癌患者的个体化治疗提供指导。方法采用PCR测序法分析259例结直肠癌患者ERCC1的基因多态性。结果男性患者ERCC1的基因型主要为C/C (占55.71%),其次是C/T (占37.86%),T/T基因型仅占6.43%;女性患者的基因型也主要是C/C (占59.66%),其次是C/T (占36.97%),T/T基因型仅占3.36%。25~44岁患者中,基因型主要为C/C (占51.72%),其次是C/T (占41.38%),T/T基因型仅占6.90%;>44~59患者中,基因型主要为C/C (占57.95%),其次是C/T (占40.91%),T/T基因型仅占1.14%;>59岁患者中,基因型主要为C/C (占58.45%),其次是C/T (占34.51%),T/T基因型仅占7.04%。结论结直肠癌患者ERCC1的基因型主要为C/C。
目的:分析結直腸癌患者切除脩複交扠互補基因1(ERCC1)的基因多態性,以期能為結直腸癌患者的箇體化治療提供指導。方法採用PCR測序法分析259例結直腸癌患者ERCC1的基因多態性。結果男性患者ERCC1的基因型主要為C/C (佔55.71%),其次是C/T (佔37.86%),T/T基因型僅佔6.43%;女性患者的基因型也主要是C/C (佔59.66%),其次是C/T (佔36.97%),T/T基因型僅佔3.36%。25~44歲患者中,基因型主要為C/C (佔51.72%),其次是C/T (佔41.38%),T/T基因型僅佔6.90%;>44~59患者中,基因型主要為C/C (佔57.95%),其次是C/T (佔40.91%),T/T基因型僅佔1.14%;>59歲患者中,基因型主要為C/C (佔58.45%),其次是C/T (佔34.51%),T/T基因型僅佔7.04%。結論結直腸癌患者ERCC1的基因型主要為C/C。
목적:분석결직장암환자절제수복교차호보기인1(ERCC1)적기인다태성,이기능위결직장암환자적개체화치료제공지도。방법채용PCR측서법분석259례결직장암환자ERCC1적기인다태성。결과남성환자ERCC1적기인형주요위C/C (점55.71%),기차시C/T (점37.86%),T/T기인형부점6.43%;녀성환자적기인형야주요시C/C (점59.66%),기차시C/T (점36.97%),T/T기인형부점3.36%。25~44세환자중,기인형주요위C/C (점51.72%),기차시C/T (점41.38%),T/T기인형부점6.90%;>44~59환자중,기인형주요위C/C (점57.95%),기차시C/T (점40.91%),T/T기인형부점1.14%;>59세환자중,기인형주요위C/C (점58.45%),기차시C/T (점34.51%),T/T기인형부점7.04%。결론결직장암환자ERCC1적기인형주요위C/C。
Objective To analyze the polymorphism of excision repair cross-completion gene 1(ERCC1) in colorectal cancer pa-tients ,and to provide guidance for personalized therapy of colorectal cancer .Methods The polymorphism of ERCC1 in 259 patients with colorectal cancer was detected by PCR .Results The genotype of ERCC1 was mainly C/C(55 .71% ) in male patients ,and then C/T(37 .86% ) ,the genotype of T/T accounted for 6 .43% .The genotype of ERCC1 was also mainly C/C(59 .66% ) in female pa-tients ,and then C/T(36 .97% ) ,the genotype of T/T accounted for 3 .36% .The genotype was mainly C/C(51 .72% ) aged 25 to 44 patients ,and then C/T(41 .38% ) ,the genotype of T/T accounted for 6 .90% .The genotype was mainly C/C(57 .95% ) aged more than 44 to 59 patients ,and then C/T (40 .91% ) ,the genotype of T/T accounted for 1 .14% .The genotype was mainly C/C (58 .45% ) aged more than 59 patients ,and then C/T(34 .51% ) ,the genotype of T/T accounted for 7 .04% .Conclusion The poly-morphism of ERCC1 is mainly C/C in colorectal cancer patients .