CAJ | 학술논문

目的：探讨乙型肝炎病毒（HBV）感染患者血清中甘露糖结合凝集素（MBL）浓度变化及意义。方法检测250例HBV感染者（病例组）及150例对照组的MBL浓度，并比较分析二者的差异。结果病例组MBL浓度高于对照组（t＝7．097， P＜0．01）。病例组中高载量组MBL浓度与对照组比较差异有统计学意义（t＝7．179，P＜0．01），低载量组MBL浓度与对照组比较差异有统计学意义（t＝4．404，P＜0．01）。结论检测HBV感染患者血清MBL浓度的变化对了解病情，观察疗效有重要的临床价值。
목적：탐토을형간염병독（HBV）감염환자혈청중감로당결합응집소（MBL）농도변화급의의。방법검측250례HBV감염자（병례조）급150례대조조적MBL농도，병비교분석이자적차이。결과병례조MBL농도고우대조조（t＝7．097， P＜0．01）。병례조중고재량조MBL농도여대조조비교차이유통계학의의（t＝7．179，P＜0．01），저재량조MBL농도여대조조비교차이유통계학의의（t＝4．404，P＜0．01）。결론검측HBV감염환자혈청MBL농도적변화대료해병정，관찰료효유중요적림상개치。
Objective To explore the concentration of mannan-binding lectin(MBL ) of patients with chronic hepatitis B virus (HBV) .Methods Serum MBL concentrations of 250 patients(case group) with HBV and 150 healthy controls(control group) were measured .Results The serum MBL concentration in case group was higher than that in control group(t=7 .097 ,P<0 .01) . The serum MBL concentration in high HBV-DNA loading group was higher than that in control group(t=7 .179 ,P<0 .01) .The serum MBL concentration in low HBV-DNA loading group was higher than that in control group(t=4 .404 ,P<0 .01) .Conclusion Detection of serum MBL in patients with HBV will be clinically useful for understanding state of an illness and observing the cur-ative effect .