CAJ | 학술논문

目的：检测急性乳腺炎患者乳汁中细菌的分布和耐药性，为临床合理使用抗菌药物提供重要依据。方法对114例急性乳腺炎患者的乳汁标本进行细菌培养、鉴定和药物敏感试验。结果114例标本共分离细菌67株，检出率为58．8％。主要细菌分别为金黄色葡萄球菌[50．7％（34/67）]和表皮葡萄球菌[44．8％（30/67）]，其他细菌包括大肠埃希菌[1．49％（1/67）]、肺炎克雷伯菌[1．49％（1/67）]、醋酸不动杆菌[1．49％（1/67）]。耐甲氧西林凝固酶阳性金黄色葡萄球菌（M RS A ）与耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）的检出率分别为8．8％与46．7％。3株MRSA对米诺环素、万古霉素、替考拉宁和呋喃妥因的敏感率均为100．0％，31株甲氧西林敏感凝固酶阳性金黄色葡萄球菌（MSSA）对万古霉素、替考拉宁、左氧氟沙星、呋喃妥因、苯唑西林的敏感率均为100．0％，16株甲氧西林敏感凝固酶阴性葡萄球菌（MSCNS）对米诺环素、利福平、呋喃妥因、万古霉素、替考拉宁和苯唑西林的敏感率均为100．0％，14株M RC N S对万古霉素、替考拉宁、米诺环素和呋喃妥因的敏感率均为100．0％。M RS A、MSSA、MSCNS、MRCNS对青霉素的耐药率均为100．0％。结论急性乳腺炎患者乳汁中细菌主要为葡萄球菌，青霉素不应作为首选治疗的抗菌药物。
목적：검측급성유선염환자유즙중세균적분포화내약성，위림상합리사용항균약물제공중요의거。방법대114례급성유선염환자적유즙표본진행세균배양、감정화약물민감시험。결과114례표본공분리세균67주，검출솔위58．8％。주요세균분별위금황색포도구균[50．7％（34/67）]화표피포도구균[44．8％（30/67）]，기타세균포괄대장애희균[1．49％（1/67）]、폐염극뢰백균[1．49％（1/67）]、작산불동간균[1．49％（1/67）]。내갑양서림응고매양성금황색포도구균（M RS A ）여내갑양서림응고매음성포도구균（MRCNS）적검출솔분별위8．8％여46．7％。3주MRSA대미낙배소、만고매소、체고랍저화부남타인적민감솔균위100．0％，31주갑양서림민감응고매양성금황색포도구균（MSSA）대만고매소、체고랍저、좌양불사성、부남타인、분서서림적민감솔균위100．0％，16주갑양서림민감응고매음성포도구균（MSCNS）대미낙배소、리복평、부남타인、만고매소、체고랍저화분서서림적민감솔균위100．0％，14주M RC N S대만고매소、체고랍저、미낙배소화부남타인적민감솔균위100．0％。M RS A、MSSA、MSCNS、MRCNS대청매소적내약솔균위100．0％。결론급성유선염환자유즙중세균주요위포도구균，청매소불응작위수선치료적항균약물。
Objective To investigate the distribution and antibiotic resistance characteristics of pathogen in mastitis patients and to provide important foundation for clinical rational antibiotic use .Methods The bacterial isolates from 114 mastitis specimens were collected .Identification and antimicrobial susceptibility testing were carried out .Results A total of 67 strains were isolated from clinical specimen ,in which Staphylococcus aureus[50 .7% (34/67)] and Staphylococcus epidermidis[44 .8% (30/67)] were themostcommonisolate,also Escherichiacoli[1.49% (1/67)],Klebsiellapneumoniae[1.49% (1/67)]andAcinetobactercalcoace-ticus[1 .49% (1/67)] were isolated .The rates of methicillin-resistant Staphylococcus aureus(MRSA) and methicillin-resistance to coagulase-negative Staphylococci(MRCNS) were 8 .8% and 46 .7% ,respectively .The sensitive rates of minocycline ,vancomycin , teicoplanin ,furadantin to MRSA strains were 100 .0% .The sensitive rates of vancomycin ,teicoplanin ,levofloxacin ,furadantin and oxacillin to methicillin-sensitive Staphylococcus aureus(MSSA) were 100 .0% .The sensitive rates of minocycline ,rifampin ,furadan-tin ,vancomycin ,teicoplanin and oxacillin to methicillin-sensitive to coagulase-negative Staphylococci(MSCNS) were 100 .0% .The sensitive rates of vancomycin ,teicoplanin ,minocycline and furadantin to MRCNS were 100 .0% .The resistance rates of penicillin to MRSA ,MSSA ,MSCNS ,MRCNS were 100 .0% .Conclusion Staphylococcus is the main pathogen of mastitis patients .Penicillin is not a first selective drug for acute mastitis .