CAJ | 학술논문

以1％甲酸溶液-乙腈为流动相，经C18柱（250 mm ×4.6 mm，5μm）分离，通过串联ESI质谱在线检测，获得相关的色谱和质谱信息。根据研究结果推测光降解主要产物为1-（（2′-1H-双吖丙啶-3-基-[1，1′-联苯]-4-基）甲基）-2-乙氧基-1H-苯并[d]咪唑-7-羧酸，酸降解主要产物为2-氧代-3-（（2′-（5-氧代-4，5-二氢-1，2，4-噁二唑酮-3-基）-[1，1′-联苯]-4-基）甲基）-2，3-二氢-1H-苯并[d]咪唑-4-羧酸。
이1％갑산용액-을정위류동상，경C18주（250 mm ×4.6 mm，5μm）분리，통과천련ESI질보재선검측，획득상관적색보화질보신식。근거연구결과추측광강해주요산물위1-（（2′-1H-쌍아병정-3-기-[1，1′-련분]-4-기）갑기）-2-을양기-1H-분병[d]미서-7-최산，산강해주요산물위2-양대-3-（（2′-（5-양대-4，5-이경-1，2，4-오이서동-3-기）-[1，1′-련분]-4-기）갑기）-2，3-이경-1H-분병[d]미서-4-최산。
The HPLC separation experiments were performed on aC 18 column (250mm ×4.6mm, 5μm), with 1%formic acid-acetonitrile as mobile phase.The analytics were determined by ESI -MS.The chromatograms and mass spectra of forced degradation products of azilsartan were obtained by LC -MS.The structure of impurities were confirmed as 1-((2'-(1H-diazirin-3-yl) -[1,1'-biphenyl] -4-yl)methyl) -2-ethoxy-1H-benzo[d] imidazole-7-carboxylic acid, 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl) -[1,1'-biphenyl] -4-yl)methyl)-2,3-dihydro-1H-benzo[d] imidazole-4-carboxylic acid, respectively.