CAJ | 학술논문

目的：通过老年抑郁症合并慢性心衰患者血清中N末端-前B型钠尿肽(NT-proBNP)和同型半胱氨酸(Hcy)的监测，观察其临床变化对老年抑郁症慢性心衰患者的诊断价值和近期疗效评估。方法选择经临床确诊的老年抑郁症慢性心衰患者(NYHAⅠ~郁级)80例(A组)及体检健康者50例(B组)，分别检测其NT-proBNP和Hcy水平。并检测A组经正规治疗后NT-proBNP和Hcy水平变化，对检测结果对比分析。结果A组患者NT-proBNP(u=9.55)和Hcy(u=9.24)水平明显高于B组，差异有显著统计学意义(P<0.01)。 A组患者治疗后NT-proBNP(u=4.83)和Hcy(u=7.65)的水平显著低于治疗前，差异有显著统计学意义(P<0.01)。结论将NT-proBNP和Hcy联合检测有助于老年抑郁症合并慢性心衰的诊断，并可作为近期疗效评价指标。
목적：통과노년억욱증합병만성심쇠환자혈청중N말단-전B형납뇨태(NT-proBNP)화동형반광안산(Hcy)적감측，관찰기림상변화대노년억욱증만성심쇠환자적진단개치화근기료효평고。방법선택경림상학진적노년억욱증만성심쇠환자(NYHAⅠ~욱급)80례(A조)급체검건강자50례(B조)，분별검측기NT-proBNP화Hcy수평。병검측A조경정규치료후NT-proBNP화Hcy수평변화，대검측결과대비분석。결과A조환자NT-proBNP(u=9.55)화Hcy(u=9.24)수평명현고우B조，차이유현저통계학의의(P<0.01)。 A조환자치료후NT-proBNP(u=4.83)화Hcy(u=7.65)적수평현저저우치료전，차이유현저통계학의의(P<0.01)。결론장NT-proBNP화Hcy연합검측유조우노년억욱증합병만성심쇠적진단，병가작위근기료효평개지표。
Objective To evaluate the efficacy and diagnostic value of NT-proBNP and homocysteine (Hcy) levels in the serum of elderly depression with chronic heart failure. Methods The clinical diagnosis of depression in the elderly patients with chronic heart failure (NYHAⅠ-Ⅳ grade)80 cases (group A)and 50 cases of healthy subjects(group B), NT-proBNP and Hcy levels were detected. Well which were detected in group A,comparative analysis of results before and after conventional therapy. Results The levels of NT-proBNP(u=9.55) and Hcy (u=9.24) was significantly higher in group A than those in group B, the difference was statistically significant (P<0.01). And the levels of NT-proBNP (u=4.83)and Hcy (u=7.65)were significantly lower in group A after treatment than those of before treatment,the difference was statistically significant(P<0.01). Conclusion NT-proBNP and Hcy joint detection can help diagnose depression in the elderly patients with chronic heart failure,and as a short-term effect evaluation.