CAJ | 학술논문

目的：探讨PHLPP在非小细胞肺癌(NSCLC)中的表达及临床意义。方法采用免疫组织化学染色的方法检测82例NSCLC组织中PHLPP蛋白的表达情况，并结合临床及病理因素进行相关性分析。结果 PHLPP主要在细胞膜上表达，在NSCLC中63%阴性表达、11%为+、10%为++、16%为+++，PHLPP的表达与NSCLC的分化程度存在显著相关性(P=0.024)，与年龄、性别、吸烟状况、病理类型及分期没有显著相关性。结论 PHLPP蛋白在人NSCLC组织中表达率为37%，与NSCLC的分化程度有相关性。
목적：탐토PHLPP재비소세포폐암(NSCLC)중적표체급림상의의。방법채용면역조직화학염색적방법검측82례NSCLC조직중PHLPP단백적표체정황，병결합림상급병리인소진행상관성분석。결과 PHLPP주요재세포막상표체，재NSCLC중63%음성표체、11%위+、10%위++、16%위+++，PHLPP적표체여NSCLC적분화정도존재현저상관성(P=0.024)，여년령、성별、흡연상황、병리류형급분기몰유현저상관성。결론 PHLPP단백재인NSCLC조직중표체솔위37%，여NSCLC적분화정도유상관성。
Objective To investigate the expression of PHLPP in non-small cell lung cancer (NSCLC)and its correla-tions of clinicopathological characteristics. Methods All of 82 tissue specimens with NSCLC were examined with im-munohistochemical staining, and the results of IHC were analyzed with the clinicopathologic characteristics. Results PHLPP mainly expressed on the cell membrane. The rate of PHLPP expression was negative in 63%, poor in 11%, moderate in 10% and strong in 16%, respectively. The expression of PHLPP was significantly correlated with differen-tiation, but not with age, smoking states, pathological type and stage. Conclusion The positive expression rate of PHLPP is 37%in human NSCLC tissue specimens and was correlated with histological differentiation .