中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2014年
28期
153-156
,共4页
手足口病%重症高危型%救治%疗效观察
手足口病%重癥高危型%救治%療效觀察
수족구병%중증고위형%구치%료효관찰
Hand-foot-and-mouth disease%Severe high-risk type%Treatment%Curative effect observation
目的：总结手足口病(HFMD)重症高危患儿的临床特点及治疗方案。方法回顾性分析2009年4月~2011年8月东莞市石龙人民医院3693例HFMD患儿的临床资料，根据疾病严重程度将其分为普通组3608例，重症组85例。比较两组患儿临床表现、实验室检查及治疗效果。结果HFMD高危重症患儿病情较重，更易惊厥和(或)昏迷，皮肤四肢末梢较凉，皮肤多呈花纹状，其发热病程更久，血压及心率较普通HFMD高；普通组白细胞(WBC)[(9.32±3.01)×109/L]、血糖[(7.00±2.98)mmol/L]及乳酸水平[(1.81±0.82)mmol/L]均低于重症组[(10.14±3.65)×109/L、(8.51±4.71)mmol/L、(2.29±1.82)mmol/L]，差异均有统计学意义(t=2.678、4.301、3.582，P=0.0245、0.0096、0.0248)；普通组总有效率为96.4%，明显高于重症组(81.2%)，差异有高度统计学意义(χ2=49.225，P <0.01)。结论HFMD重症高危患儿病情发展迅速，血糖、血压、WBC均升高，神经系统、呼吸系统及循环系统均受到影响，故临床上应当积极干预，阻止疾病向重症发展。
目的：總結手足口病(HFMD)重癥高危患兒的臨床特點及治療方案。方法迴顧性分析2009年4月~2011年8月東莞市石龍人民醫院3693例HFMD患兒的臨床資料，根據疾病嚴重程度將其分為普通組3608例，重癥組85例。比較兩組患兒臨床錶現、實驗室檢查及治療效果。結果HFMD高危重癥患兒病情較重，更易驚厥和(或)昏迷，皮膚四肢末梢較涼，皮膚多呈花紋狀，其髮熱病程更久，血壓及心率較普通HFMD高；普通組白細胞(WBC)[(9.32±3.01)×109/L]、血糖[(7.00±2.98)mmol/L]及乳痠水平[(1.81±0.82)mmol/L]均低于重癥組[(10.14±3.65)×109/L、(8.51±4.71)mmol/L、(2.29±1.82)mmol/L]，差異均有統計學意義(t=2.678、4.301、3.582，P=0.0245、0.0096、0.0248)；普通組總有效率為96.4%，明顯高于重癥組(81.2%)，差異有高度統計學意義(χ2=49.225，P <0.01)。結論HFMD重癥高危患兒病情髮展迅速，血糖、血壓、WBC均升高，神經繫統、呼吸繫統及循環繫統均受到影響，故臨床上應噹積極榦預，阻止疾病嚮重癥髮展。
목적：총결수족구병(HFMD)중증고위환인적림상특점급치료방안。방법회고성분석2009년4월~2011년8월동완시석룡인민의원3693례HFMD환인적림상자료，근거질병엄중정도장기분위보통조3608례，중증조85례。비교량조환인림상표현、실험실검사급치료효과。결과HFMD고위중증환인병정교중，경역량궐화(혹)혼미，피부사지말소교량，피부다정화문상，기발열병정경구，혈압급심솔교보통HFMD고；보통조백세포(WBC)[(9.32±3.01)×109/L]、혈당[(7.00±2.98)mmol/L]급유산수평[(1.81±0.82)mmol/L]균저우중증조[(10.14±3.65)×109/L、(8.51±4.71)mmol/L、(2.29±1.82)mmol/L]，차이균유통계학의의(t=2.678、4.301、3.582，P=0.0245、0.0096、0.0248)；보통조총유효솔위96.4%，명현고우중증조(81.2%)，차이유고도통계학의의(χ2=49.225，P <0.01)。결론HFMD중증고위환인병정발전신속，혈당、혈압、WBC균승고，신경계통、호흡계통급순배계통균수도영향，고림상상응당적겁간예，조지질병향중증발전。
Objective To discuss the clinical characteristics and treatment options of the hand-foot-mouth disease (HFMD). Methods 160 children with HFMD from April 2009 to August 2011 in Shilong Dongguan People's Hospital of Dongguan City were retrospectively analyzed. All the cases were divided into two groups according to the severity of disease, 54 cases in the normal group, 106 cases in the serious group. The clinical manifestations, laboratory results and treatment effect of the two groups were compared. Results The serious children with heavier, more convulsion and coma, skin limbs endings cooler, and more decorative pattern, the heating duration longer, showed a high blood pres-sure and heart rate than ordinary HFMD. The WBC, blood sugar, lactic acid levels of serious group were (9.32±3.01)í109/L, (7.00±2.98) mmol/L, (1.81±0.82) mmol/L respectively, lower than those of the normal group [(10.14±3.65)í109/L, (8.51±4.71) mmol/L, (2.29±1.82) mmol/L], the differences were statistically significant (t=2.678, 4.301, 3.582;P=0.0245, 0.0096, 0.0248). The total effective rate of the normal group was 96.4%, higher than that of the serious group (81.2%), the difference was statistically significant (χ2=49.225, P<0.001). Conclusion The children with severe HFMD should actively intervention, give active intervention, prevent disease to intensive development.
