CAJ | 학술논문

目的：探讨人表皮生长因子受体2（ HER2）基因与新疆维吾尔族（维族）、汉族胃癌患者临床病理特征的相关性及其临床意义。方法采用免疫组织化学染色及荧光原位杂交检测108例汉族和52例维族患者胃癌组织中HER2状态的表达，并预测其对胃癌预后的影响。结果160例患者HER2基因表达总阳性率为10．00％（16／160），维族HER2基因表达阳性率为15．38％（8／52），汉族HER2基因表达阳性率为7．41％（8／108）。 HER2基因表达阳性与性别、年龄、族别、肿瘤大小、肿瘤病理类型、TNM分期、浸润深度、淋巴结转移、远处转移、神经是否受侵、淋巴管内是否有癌栓、贫血及癌胚抗原无相关性（P均＞0．05），而与肿瘤部位、Lauren分型及分化程度相关（P均＜0．05）。结论 HER2基因检测可以作为评估新疆维汉民族胃癌恶性生物学行为及预后的指标。
목적：탐토인표피생장인자수체2（ HER2）기인여신강유오이족（유족）、한족위암환자림상병리특정적상관성급기림상의의。방법채용면역조직화학염색급형광원위잡교검측108례한족화52례유족환자위암조직중HER2상태적표체，병예측기대위암예후적영향。결과160례환자HER2기인표체총양성솔위10．00％（16／160），유족HER2기인표체양성솔위15．38％（8／52），한족HER2기인표체양성솔위7．41％（8／108）。 HER2기인표체양성여성별、년령、족별、종류대소、종류병리류형、TNM분기、침윤심도、림파결전이、원처전이、신경시부수침、림파관내시부유암전、빈혈급암배항원무상관성（P균＞0．05），이여종류부위、Lauren분형급분화정도상관（P균＜0．05）。결론 HER2기인검측가이작위평고신강유한민족위암악성생물학행위급예후적지표。
Objective To investigate the correlation between HER 2 gene expression and clinicopathological character-istics of gastric carcinoma cases in the Uighurs and Han nationality in Xinjiang .Methods HER2 gene expression was ex-amined by immunohistochemistry and fluorescence in situ hybridization in 160 gastric adenocarcinoma specimens .Results The positive rate of HER2 gene overespression was 10.00%(16/160) which was 15.38%(8/52)and 7.41%(8/108) in the Uighurs and Han nationality respectively .HER2 gene overespression was associated with tumor location ,lauren and differentiation (all P<0.05), but not with sex, age, nationality, tumor size, tumor diameter, pathological type, TNM stage, invasion depth, lymph node metastasis,distant metastasis, neural invasion, lymphatic or thrombus, anemia and car-cinoembryonic antigen (all P>0.05).Conclusion Detection of HER2 gene expression may be used to assess the malig-nant biological behavior and prognosis of gastric cancer in the Uighurs and Han nationality in Xinjiang .