CAJ | 학술논문

1987年，由Selker等在粗糙脉孢菌中首次发现重复序列诱导点突变（ repeat-induced point mu-tation，RIP）。在重复序列诱导点突变过程中，搜寻前减数分裂组织单倍体核中DNA的重复序列，然后发生众多的碱基C到T的突变，产生富碱基T＋A片段，从而使重复序列中的G-C碱基对发生转换突变成为A-T碱基对。此外，发生RIP的序列多集中在着丝粒区域，主要是转座子甲基化后的遗迹。移动转座子是真核生物基因组进化的主要驱动力。对于真菌，重复序列诱导点突变（ RIP）在减数分裂过程中通过突变多拷贝DNA，能最大限度地减少转座子的影响，因此对RIP的研究在一定程度上能有助于了解基因组进化的真谛。综述了重复序列诱导点突变的产生机制，以及真菌中重复序列诱导点突变的研究进展。
1987년，유Selker등재조조맥포균중수차발현중복서렬유도점돌변（ repeat-induced point mu-tation，RIP）。재중복서렬유도점돌변과정중，수심전감수분렬조직단배체핵중DNA적중복서렬，연후발생음다적감기C도T적돌변，산생부감기T＋A편단，종이사중복서렬중적G-C감기대발생전환돌변성위A-T감기대。차외，발생RIP적서렬다집중재착사립구역，주요시전좌자갑기화후적유적。이동전좌자시진핵생물기인조진화적주요구동력。대우진균，중복서렬유도점돌변（ RIP）재감수분렬과정중통과돌변다고패DNA，능최대한도지감소전좌자적영향，인차대RIP적연구재일정정도상능유조우료해기인조진화적진체。종술료중복서렬유도점돌변적산생궤제，이급진균중중복서렬유도점돌변적연구진전。
Repeat -induced point mutations ( RIP) was discovered in Neurospora crassa in 1987 by Selker. RIP searches for sequence duplications in haploid nuclei of premeiotic tissue and then litters them with numerous C to T mutations.T+A rich fragments so that the G-C pairs in duplications can be mutated to A -T.In addition, RIP’ s sequences , which are concentrated in centromeric regions , and are predominantly relics of transposons , are left methylated .Mobile transposable elements are among the primary drivers of the evolution of eukaryotic genomes . For fungi , repeat-induced point mutation ( RIP) silencing minimizes deleterious effects of transposons by mutating multicopy DNA during meiosis .To explore the impact of RIP-mutated transposons is conducive to generate evolu-tionary inferences for phylogenetic and population genetic analyses .The paper has reviewed the mechanism of RIP and the progress of RIP in fungi .