中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2009年
1期
73-75
,共3页
管维平%李辉%目时弘文%管静芝
管維平%李輝%目時弘文%管靜芝
관유평%리휘%목시홍문%관정지
高脂血症%脑梗死%低密度脂蛋白胆固醇
高脂血癥%腦梗死%低密度脂蛋白膽固醇
고지혈증%뇌경사%저밀도지단백담고순
Hyperlipidaemia%Cerebral infarction%Oxidative low-density lipoprotein
目的 了解脑梗死患者不同程度的高脂血症对LDL-C氧化敏感性的影响.方法 合并高脂血症的大脑中动脉区域的脑梗死患者61例,其病灶大小相似.按照以下标准对高脂血症(mmol/L)进行分级:Ⅰ级(TC 5.72～6.24 mmol/L:HDL-C 0.78～1.04 mmol/L:LDL-C 3.64～4.16 mmol/L;TG 3.90～4.42mmol/L)20例.Ⅱ级(TC 6.24～6.76 mmol//L;HDL-C O.52～0.78 mmoL/L;LDL- 4.16～4.68 mmol/L;TG4.42～4.94 mmol/L)19例.Ⅲ级(TC＞6.76 mmol/L;HDL-C＜0.52 mmol/L;LDL.C＞4.68 mmol/L;TG＞4.94 mmol/L)22例.铜氧化共轭双烯法测定血LDL-C体外氧化延迟时间.结果 脑梗死患者中高血脂的分级与LDL-C体外氧化延迟时间[Ⅰ、Ⅱ、Ⅲ级分别为(81.26±7.92)、(71.84±9.75)、(60.95±9.33)min]呈负相关(r=-0.751,P＜0.01).结论 脑梗死患者中LDL-C的氧化敏感性随血脂水平的升高而增强.
目的 瞭解腦梗死患者不同程度的高脂血癥對LDL-C氧化敏感性的影響.方法 閤併高脂血癥的大腦中動脈區域的腦梗死患者61例,其病竈大小相似.按照以下標準對高脂血癥(mmol/L)進行分級:Ⅰ級(TC 5.72～6.24 mmol/L:HDL-C 0.78～1.04 mmol/L:LDL-C 3.64～4.16 mmol/L;TG 3.90～4.42mmol/L)20例.Ⅱ級(TC 6.24～6.76 mmol//L;HDL-C O.52～0.78 mmoL/L;LDL- 4.16～4.68 mmol/L;TG4.42～4.94 mmol/L)19例.Ⅲ級(TC＞6.76 mmol/L;HDL-C＜0.52 mmol/L;LDL.C＞4.68 mmol/L;TG＞4.94 mmol/L)22例.銅氧化共軛雙烯法測定血LDL-C體外氧化延遲時間.結果 腦梗死患者中高血脂的分級與LDL-C體外氧化延遲時間[Ⅰ、Ⅱ、Ⅲ級分彆為(81.26±7.92)、(71.84±9.75)、(60.95±9.33)min]呈負相關(r=-0.751,P＜0.01).結論 腦梗死患者中LDL-C的氧化敏感性隨血脂水平的升高而增彊.
목적 료해뇌경사환자불동정도적고지혈증대LDL-C양화민감성적영향.방법 합병고지혈증적대뇌중동맥구역적뇌경사환자61례,기병조대소상사.안조이하표준대고지혈증(mmol/L)진행분급:Ⅰ급(TC 5.72～6.24 mmol/L:HDL-C 0.78～1.04 mmol/L:LDL-C 3.64～4.16 mmol/L;TG 3.90～4.42mmol/L)20례.Ⅱ급(TC 6.24～6.76 mmol//L;HDL-C O.52～0.78 mmoL/L;LDL- 4.16～4.68 mmol/L;TG4.42～4.94 mmol/L)19례.Ⅲ급(TC＞6.76 mmol/L;HDL-C＜0.52 mmol/L;LDL.C＞4.68 mmol/L;TG＞4.94 mmol/L)22례.동양화공액쌍희법측정혈LDL-C체외양화연지시간.결과 뇌경사환자중고혈지적분급여LDL-C체외양화연지시간[Ⅰ、Ⅱ、Ⅲ급분별위(81.26±7.92)、(71.84±9.75)、(60.95±9.33)min]정부상관(r=-0.751,P＜0.01).결론 뇌경사환자중LDL-C적양화민감성수혈지수평적승고이증강.
Objective To determine the influence of hyperlipidaemia on the oxidative susecptivity of plasma low-density lipoprotein in patients with cerebral infarction.Methods The oxidative susceptivity of plasma low-density lipoprotein were determined in 61 patients with cerebral infarction accompanied by hyperlipidemia in the region of middle cerebral artery,and the size of infarction was resemble.The patients were divided according to the standard of hyperlipidemia below:20 patients were confirmed pertaining to stage Ⅰ(total cholesterol,5.72-6.24 mmol/L;high density lipoprotein,0.78-1.04 mmol/L;low-density lipoprotein 3.64-4.16 mmol/L;triglyeride,3.90-4.42 mmol/L),19 patients were confirmed pertaining to stage Ⅱ(total cholesterol,6.24-6.76 mmol/L;high density lipoprotein,0.52-0.78 mmol/L;low-density lipoprotein,4.16-4.68 mmol/L;triglyeride,4.42-4.94 mmol/L),and 22 patients were confirmed pertaining to stage Ⅲ(total cholesterol,＞6.76;high density lipoprotein,＜0.52 mmoL/L;low-density lipoprotein,＞4.68 mmol/L;triglyeride,＞4.94 mmol/L).Low-density lipoprotein oxidizability was measured by determining the lag time in conjugated diene production at 234 nm by copper-stimulated oxidation.Results The lag time in conjugated diene production in patients with cerebral infarction was negatively correlated with the stage Ⅰ,Ⅱ,Ⅲ of hyperlipidemia in all the subjects(stage Ⅰ,(81.26±7.92)rain;stage Ⅱ,(71.84±9.75)rain;stage Ⅲ,(60.95±9.33)rain.respectively,r=0.751,P＜0.01).Conclusion The oxidative susceptivity of plasma low-density lipoprotein is increased with the increase of hyperlipidemia levels in patients with cerebral infarction.
