CAJ | 학술논문

目的：探讨抗β2-糖蛋白I抗体和复发性流产的关系。方法收集2012年1月1日至12月31日就诊于山东大学附属山东省立医院的210名抗心磷脂抗体阴性的复发性流产患者和80例正常经产妇的临床资料，检测其血清中的抗β2-糖蛋白I抗体水平，并分析复发性流产患者接受抗凝治疗的效果，以及探讨该类患者接受抗凝治疗的抗β2-糖蛋白I抗体水平。结果（1）复发性流产患者抗β2-糖蛋白I抗体主要与IgM抗体相关，本研究中210例复发性流产患者抗β2-糖蛋白I抗体IgM阳性人数为48例，发生率为22.9％。（2）对于抗β2-糖蛋白I抗体IgM为15～20 RU/ml的复发性流产患者，采取抗凝治疗的妊娠成功率（66.7％，14/21）明显高于未接受抗凝治疗者（19.4％，6/31），差异有统计学意义（礸2＝11.840，P＜0.05）。（3）对于抗β2-糖蛋白I抗体IgM≥15 RU/ml的复发性流产患者，采取抗凝治疗的妊娠成功率（70.6％，36/100）明显高于未接受抗凝治疗者（18.4％，9/49），差异有统计学意义（礸2＝27.535，P＜0.05）。结论抗β2-糖蛋白I 抗体IgM和复发性流产有相关性，当抗β2-糖蛋白I抗体IgM≥15 RU/ml即可采取抗凝治疗。
목적：탐토항β2-당단백I항체화복발성유산적관계。방법수집2012년1월1일지12월31일취진우산동대학부속산동성립의원적210명항심린지항체음성적복발성유산환자화80례정상경산부적림상자료，검측기혈청중적항β2-당단백I항체수평，병분석복발성유산환자접수항응치료적효과，이급탐토해류환자접수항응치료적항β2-당단백I항체수평。결과（1）복발성유산환자항β2-당단백I항체주요여IgM항체상관，본연구중210례복발성유산환자항β2-당단백I항체IgM양성인수위48례，발생솔위22.9％。（2）대우항β2-당단백I항체IgM위15～20 RU/ml적복발성유산환자，채취항응치료적임신성공솔（66.7％，14/21）명현고우미접수항응치료자（19.4％，6/31），차이유통계학의의（찰2＝11.840，P＜0.05）。（3）대우항β2-당단백I항체IgM≥15 RU/ml적복발성유산환자，채취항응치료적임신성공솔（70.6％，36/100）명현고우미접수항응치료자（18.4％，9/49），차이유통계학의의（찰2＝27.535，P＜0.05）。결론항β2-당단백I 항체IgM화복발성유산유상관성，당항β2-당단백I항체IgM≥15 RU/ml즉가채취항응치료。
Objective To explore the relation between anti β2-glycoprotein I antibodies and recurrent abortion.Methods This study collected the clinical data of 210 recurrent abortion patients with anticardiolipin antibody negative and 80 normal multiparas, who were admitted in the Shandong Provincial Hospital Affiliated to Shandong University from January 1st to December 31st 2012.To explored the level of antiβ2-glycoprotein I antibody immunoglobulin M ( IgM ) for treating the recurrent abortion, serum antiβ2-glycoprotein I antibodies of the patients were collected and anticoagulant therapy effects of the recurrent abortion patients were analyzed.Results ( 1 ) The recurrent abortion patients were related with antiβ2-glycoprotein I antibody IgM. Among the 210 recurrent abortion patients, 48 patients were antiβ2-glycoprotein I antibody IgM positive; the incidence rate was 22.9%.( 2 ) For the recurrent abortion patients with 15-20 RU/ml anti β2-glycoprotein I antibody IgM, the successful pregnancy rate in anticoagulant therapy group ( 66.7%, 14/21 ) were significantly higher than that in control group (19.4%,6/31), (χ2 =11.840, P value <0.05).(3) For the recurrent abortion patients with equal or more than 15 RU/ml anti β2-glycoprotein I antibody IgM, the successful pregnancy rate in anticoagulant therapy group (70.6%, 36/100) were significantly higher than that in control group (18.4%,9/49), (χ2=27.535, P value <0.05).Conclusions There was relation between recurrent abortion patients and anti β2-glycoprotein I antibody IgM.When antiβ2-glycoprotein I antibody IgM was equal or more than