CAJ | 학술논문

目的：探讨和厚朴酚静脉注射给药后在大鼠体内的动态变化规律及其在唾液中的分布情况。方法：大鼠尾静脉注射和厚朴酚，用反相高效液相色谱法测定和厚朴酚在血浆、唾液中的浓度，采用药动学软件3 P97分析数据，确定药动学参数。结果：和厚朴酚在大鼠体内符合二室模型分布，主要药动学参数：t1／2＝（102．980±10．600） min，AUC＝（1219．260±120．520）μg· min／mL，Vc＝（0．722±0．027） L／kg， CL＝（0．0246±0．002）L／min。结论：和厚朴酚可在唾液中检测到，给药后腮腺、颌下腺中的药物浓度与血浆中的药物浓度有一定的相关性。表明腮腺和颌下腺唾液样本将来可被用于和厚朴酚的治疗监测。
목적：탐토화후박분정맥주사급약후재대서체내적동태변화규률급기재타액중적분포정황。방법：대서미정맥주사화후박분，용반상고효액상색보법측정화후박분재혈장、타액중적농도，채용약동학연건3 P97분석수거，학정약동학삼수。결과：화후박분재대서체내부합이실모형분포，주요약동학삼수：t1／2＝（102．980±10．600） min，AUC＝（1219．260±120．520）μg· min／mL，Vc＝（0．722±0．027） L／kg， CL＝（0．0246±0．002）L／min。결론：화후박분가재타액중검측도，급약후시선、합하선중적약물농도여혈장중적약물농도유일정적상관성。표명시선화합하선타액양본장래가피용우화후박분적치료감측。
Objective:To investigate pharmacokinetics and salivary distribution of honokiol after intravenous administration of osthole to rats.Methods:Each rat was given a dose of honokiol injection via the vein.RP-HPLC method was used to determine the concentration of honokiol in plasma and saliva.Pharmacokinetic parameters were analyzed by the comput-er program 3P97.Results:Honokiol showed two compartment modesl and the main parameters of pharmacokinetics were as follows:t1/2 =(102.980 ±10.600)min, AUC=(1219.260 ±120.520)μg· min/mL,Vc=(0.722 ±0.027) L/kg, CL=(0.0246 ±0.002) L/min.Conclusion:Osthole can be detected in saliva, and the correlation is significant in parot-id and mandibular glands and plasma after administration.It is suggested that the parotid and mandibular saliva samples may be used for monitoring honokiol therapy in the future.