CAJ | 학술논문

目的：从药理角度探讨清火解毒法的镇痛抗炎作用。方法：乙酸刺激至小鼠疼痛扭体实验、小鼠热板实验，观察中药对小鼠疼痛的抑制作用；二甲苯致小鼠耳肿胀法，比较各组用药后小鼠耳壳肿胀度；醋酸诱发小鼠毛细血管通透性增加，观察中药对小鼠腹腔毛细血管通透性的影响。结果：可明显减少乙酸所致小鼠的扭体反应次数（P＜0．01）。明显提高小鼠的痛阈值（P＜0．01）。能减轻小鼠耳壳肿胀度及肿胀率（P＜0．05，P＜0．01）；降低由醋酸引起的小鼠毛细血管通透性的增加（P＜0．05）。结论：清热解毒法具有一定的镇痛抗炎作用。
목적：종약리각도탐토청화해독법적진통항염작용。방법：을산자격지소서동통뉴체실험、소서열판실험，관찰중약대소서동통적억제작용；이갑분치소서이종창법，비교각조용약후소서이각종창도；작산유발소서모세혈관통투성증가，관찰중약대소서복강모세혈관통투성적영향。결과：가명현감소을산소치소서적뉴체반응차수（P＜0．01）。명현제고소서적통역치（P＜0．01）。능감경소서이각종창도급종창솔（P＜0．05，P＜0．01）；강저유작산인기적소서모세혈관통투성적증가（P＜0．05）。결론：청열해독법구유일정적진통항염작용。
Objective: From the pharmacological point of view,to explore the analgesic and anti-inflammatory effect of clearing fire and detoxification therapy.Method:Acetic acid stimulation caused the mice to pain writhing and hot plate experiment,and observe the effect on the inhibition of pain in mice by taditional Chinese medicine.Xylen induced ear e-dema in mice, comparing the auricular swelling of the mice in each group after treatment.Acetic acid induced the addi-tion of capillary permeability in mice,and observe the impact of capillary permeability in mice by taditional Chinese med-icine.Results:Reduce the number of writhing response in mice caused by acetic acid significantly(P<0.01).Increase the pain threshold in mice significantly(P<0.01).Reduce the auricular swelling and swelling rate in mice(P<0.05, P<0.01);Reduce the addition of capillary permeability in mice caused by the acetic acid (P<0.05).Conclusion:Clearing fire and detoxification therapy has some analgesic and anti-inflammatory effects.