中国CT和MRI杂志
中國CT和MRI雜誌
중국CT화MRI잡지
CHINESE JOURNAL OF CT AND MRI
2014年
8期
111-114
,共4页
梁菊香%邓新源%罗志程%沈成威%李春梅
樑菊香%鄧新源%囉誌程%瀋成威%李春梅
량국향%산신원%라지정%침성위%리춘매
鼻咽癌%MRI%动态增强技术
鼻嚥癌%MRI%動態增彊技術
비인암%MRI%동태증강기술
Nasopharyngeal Carcinoma%Magnetic Resonance Imaging (MRI)%Dynamic Enhancement Technique
目的：本研究对鼻咽癌放疗后复查的患者行MRI动态增强检查，旨在了解肿瘤局部纤维化与复发的动态增强特点，探讨动态增强MRI技术在鼻咽癌放疗后局部复发与纤维化的鉴别诊断中的价值。方法将我院从2011年3月到2013年6月的67例经放射治疗后的鼻咽癌患者分为2组：放疗后局部纤维化组38例及复发组29例，男45例，女22例；年龄22-72岁，平均42±1.5岁。行MRI动态增强后，行常规增强T1WI扫描。测量他们注射钆喷酸葡胺(Gd-DTPA)后0s至3min期间病变同一区域各时相的T1WI信号强度。应用分析软件测量ROI的信号强度，获取两组病例动态增强的时间-信号强度曲线(TIC)并对其达峰时间(PT)、曲线最大斜率(Slopemax)、曲线下面积(AUC)三个参数进行统计学分析。结果放疗后鼻咽癌局部纤维化组达峰时间(PT)低于复发组的达峰时间，经过样本均数方差分析，纤维化组与复发组比较，差别无统计学意义(p＞0.05)。放疗后鼻咽癌患者纤维化组曲线最大斜率(Slopemax)明显低于复发组的最大斜率值(Slopemax)，差别具有统计学意义(p＜0.05)。放疗后鼻咽癌患者纤维化组曲线下面积(AUC)低于复发组的曲线下面积(AUC)，差别无统计学意义（p＞0.05）。结论 MRI动态增强技术对鼻咽癌放疗后局部复发与纤维化的鉴别具有重要的临床意义。
目的：本研究對鼻嚥癌放療後複查的患者行MRI動態增彊檢查，旨在瞭解腫瘤跼部纖維化與複髮的動態增彊特點，探討動態增彊MRI技術在鼻嚥癌放療後跼部複髮與纖維化的鑒彆診斷中的價值。方法將我院從2011年3月到2013年6月的67例經放射治療後的鼻嚥癌患者分為2組：放療後跼部纖維化組38例及複髮組29例，男45例，女22例；年齡22-72歲，平均42±1.5歲。行MRI動態增彊後，行常規增彊T1WI掃描。測量他們註射釓噴痠葡胺(Gd-DTPA)後0s至3min期間病變同一區域各時相的T1WI信號彊度。應用分析軟件測量ROI的信號彊度，穫取兩組病例動態增彊的時間-信號彊度麯線(TIC)併對其達峰時間(PT)、麯線最大斜率(Slopemax)、麯線下麵積(AUC)三箇參數進行統計學分析。結果放療後鼻嚥癌跼部纖維化組達峰時間(PT)低于複髮組的達峰時間，經過樣本均數方差分析，纖維化組與複髮組比較，差彆無統計學意義(p＞0.05)。放療後鼻嚥癌患者纖維化組麯線最大斜率(Slopemax)明顯低于複髮組的最大斜率值(Slopemax)，差彆具有統計學意義(p＜0.05)。放療後鼻嚥癌患者纖維化組麯線下麵積(AUC)低于複髮組的麯線下麵積(AUC)，差彆無統計學意義（p＞0.05）。結論 MRI動態增彊技術對鼻嚥癌放療後跼部複髮與纖維化的鑒彆具有重要的臨床意義。
목적：본연구대비인암방료후복사적환자행MRI동태증강검사，지재료해종류국부섬유화여복발적동태증강특점，탐토동태증강MRI기술재비인암방료후국부복발여섬유화적감별진단중적개치。방법장아원종2011년3월도2013년6월적67례경방사치료후적비인암환자분위2조：방료후국부섬유화조38례급복발조29례，남45례，녀22례；년령22-72세，평균42±1.5세。행MRI동태증강후，행상규증강T1WI소묘。측량타문주사구분산포알(Gd-DTPA)후0s지3min기간병변동일구역각시상적T1WI신호강도。응용분석연건측량ROI적신호강도，획취량조병례동태증강적시간-신호강도곡선(TIC)병대기체봉시간(PT)、곡선최대사솔(Slopemax)、곡선하면적(AUC)삼개삼수진행통계학분석。결과방료후비인암국부섬유화조체봉시간(PT)저우복발조적체봉시간，경과양본균수방차분석，섬유화조여복발조비교，차별무통계학의의(p＞0.05)。방료후비인암환자섬유화조곡선최대사솔(Slopemax)명현저우복발조적최대사솔치(Slopemax)，차별구유통계학의의(p＜0.05)。방료후비인암환자섬유화조곡선하면적(AUC)저우복발조적곡선하면적(AUC)，차별무통계학의의（p＞0.05）。결론 MRI동태증강기술대비인암방료후국부복발여섬유화적감별구유중요적림상의의。
Objective This study was designed to investigate the characteristics of nasopharyngeal carcinoma recurrence (RNPC) and fibrosis (RF) on dynamic enhanced magnetic resonance imaging (DMRI) technology, calculated the dynamic change of T1WI signal intensity to value of RNPC and RF based on DMRI diagnosis. Methods A total cases of 67 NPC patients of our hospital from March 2011 to June 2013 were divided into 2 groups: 38 in RF group and 29 in RNPC group, male 45 cases, female 22 cases; Age 22-72ys, average 42±1.5ys. After conventional plain MRI scan of nasopharynx, DMRI and conventional contrast enhanced T1-weighted imaging (T1WI) were performed. A circle area in tumoral parenchyma was selected as region of interest (ROI) , the T1WI signal of ROI was measured during the period from 0s to 3 mins after injection of Gb-DTPA, and the dynamic time-signal intensity curves (TIC) of the two types of turmor were obtained and compared. Maximal contrast enhancement ratio (MCER), Peak time to MCER (PT), The area under the concentration time curve (AUC) were measured. Results The PT of RF group is lower than those of RNPC group, after sample mean variance analysis, no significant differences of PT were found between the two groups (p>0.05). The Slopemax of RF group is significantly lower than those of RNPC group, with statistically significant difference (p<0.05). The AUC of RF group is lower than those of RNPC group, with no significant differences (p>0.05). Conclusion DMRI may provide important clinical information for differential diagnosis of RNPC and RF.
