CAJ | 학술논문

目的：探讨生后6~12 h 开始选择性头部亚低温治疗对新生儿缺氧缺血性脑病预后的影响。方法将中度缺氧缺血性脑病新生儿40例随机分为对照组与观察组：对照组（常温组）18例，观察组（生后6~12 h 实施亚低温）22例。所有患儿给予相同的支持对症治疗。观察组患儿给予选择性头部亚低温治疗，维持肛温（34.0±0.5）℃，持续72 h，患儿在3、6月龄时用中国标准化的贝来量表（ CDCC）测智力发育指数（ MDI）和运动发育指数（PDI）。结果两组患儿的 MDl 分别为73.2±11.2和80.7±10.3。PDl 分别为77.2±9.3和84.5±10.2。观察组 MDl、PDl 均高于对照组，差异有统计学意义（P <0.05）。结论中度缺氧缺血性脑病新生儿生后6~12 h 开始选择性头部亚低温治疗仍可有不同程度的神经保护作用。
목적：탐토생후6~12 h 개시선택성두부아저온치료대신생인결양결혈성뇌병예후적영향。방법장중도결양결혈성뇌병신생인40례수궤분위대조조여관찰조：대조조（상온조）18례，관찰조（생후6~12 h 실시아저온）22례。소유환인급여상동적지지대증치료。관찰조환인급여선택성두부아저온치료，유지항온（34.0±0.5）℃，지속72 h，환인재3、6월령시용중국표준화적패래량표（ CDCC）측지력발육지수（ MDI）화운동발육지수（PDI）。결과량조환인적 MDl 분별위73.2±11.2화80.7±10.3。PDl 분별위77.2±9.3화84.5±10.2。관찰조 MDl、PDl 균고우대조조，차이유통계학의의（P <0.05）。결론중도결양결혈성뇌병신생인생후6~12 h 개시선택성두부아저온치료잉가유불동정도적신경보호작용。
Objective:To investigate the effects of mild hypothermia therapy after birth of 6 ~ 12 h on hypoxic - ische-mic encephalopathy of neonates. Methods:All 40 cases newborns of moderate hypoxia ischemic encephalopathy were ran-domly divided into the control and observation group:the control groups(n = 18)were normal temperature,and the obser-vation group(n = 22)were treated with mild hypothermia therapy after birth of 6 ~ 12 h. All newborns were treated with the same therapy. Furthermore,the newborns in the observation group was treated with selective brain hypothermia therapy to maintain rectal temperature(34. 0 ± 0. 5)℃ for 72 h. The Chinese standardization BeNAN Scale(CDCC)was used to measure and mental development index(MDI)and motor development index(PDI)at 3 and 6 months. Results:The MDI for the two groups were 73. 2 ± 11. 2 and 80. 7 ± 10. 3,respectively. The PDI for the two groups were 77. 2 ± 93 and 84. 5 ± 10. 2,respectively. The values of MDI and PDI in the observation groups were significantly(p < 0. 05)grea-ter than that of the control group. Conclusions:The mild hypothermia therapy after birth of 6 ~ 12 h had a neuroprotective effect on hypoxic - ischemic encephalopathy of neonates.