安徽化工
安徽化工
안휘화공
ANHUI CHEMICAL INDUSTRY
2014年
5期
16-17,20
,共3页
2-(3-氯吡啶-2-基)-5-羟基吡唑-3-甲酸乙酯%3-氯-2-肼基吡啶%合成%无溶剂法
2-(3-氯吡啶-2-基)-5-羥基吡唑-3-甲痠乙酯%3-氯-2-肼基吡啶%閤成%無溶劑法
2-(3-록필정-2-기)-5-간기필서-3-갑산을지%3-록-2-정기필정%합성%무용제법
ethyl 2- (3-chloro-2-yl)-5-hydroxy-pyrazole-3-carboxylate%3-chloro-2-hydrazino-pyridine%synthesis%solvent-free method
2-(3-氯吡啶-2-基)-5-羟基吡唑-3-甲酸乙酯是合成氯虫酰胺杀虫剂的一种重要中间体。以2,3-二氯吡啶为原料经肼解、环合两步反应合成2-(3-氯吡啶-2-基)-5-羟基吡唑-3-甲酸乙酯，并对其工艺做了改进和优化，总收率43.1%。其中，3-氯-2-肼基吡啶采用无溶剂法合成，工艺过程简单。
2-(3-氯吡啶-2-基)-5-羥基吡唑-3-甲痠乙酯是閤成氯蟲酰胺殺蟲劑的一種重要中間體。以2,3-二氯吡啶為原料經肼解、環閤兩步反應閤成2-(3-氯吡啶-2-基)-5-羥基吡唑-3-甲痠乙酯，併對其工藝做瞭改進和優化，總收率43.1%。其中，3-氯-2-肼基吡啶採用無溶劑法閤成，工藝過程簡單。
2-(3-록필정-2-기)-5-간기필서-3-갑산을지시합성록충선알살충제적일충중요중간체。이2,3-이록필정위원료경정해、배합량보반응합성2-(3-록필정-2-기)-5-간기필서-3-갑산을지，병대기공예주료개진화우화，총수솔43.1%。기중，3-록-2-정기필정채용무용제법합성，공예과정간단。
Ethyl 2-(3-chloro-2-yl )-5-hydroxy-pyrazole-3-carboxylate is an important intermediate for the synthesis of pesticides chlorantraniliprole. This work described an expedient route and technology for the pyrazole synthesis using 2,3-dichloropyridine as starting material, via hydrazinolysis and cyclization with optimized total yield of 43.1%, and the hydrazinolysis process is simple with solvent-free.
