CAJ | 학술논문

目的：从炎症反应的角度探讨外用复方薰衣草油膏对烫伤豚鼠创面愈合的影响并观察其抗炎和镇痛作用。方法建立浅Ⅱ度烫伤豚鼠模型，将60只雄性豚鼠随机分为正常组、模型组、京万红组、复方薰衣草油膏高、中、低剂量组，分别外用生理盐水、京万红软膏、复方薰衣草油膏治疗，观察创面的大体变化及愈合情况，取治疗后的创面组织和血液标本，进行组织病理学检查和酶联免疫法测定血清TNF-α、IL-6、IL-8浓度；采用二甲苯耳肿胀模型和扭体法观察复方薰衣草油膏的抗炎、镇痛作用。结果外用复方薰衣草油膏使创面肿胀、渗出减轻，可能与局部组织中促炎细胞因子水平的降低有关（P ＜0.01），并显著促进豚鼠浅Ⅱ度烫伤创面的愈合（P ＜0.01），未见任何副作用；高剂量对二甲苯所致小鼠耳肿胀有抑制作用（P ＜0.01）；扭体法实验显示高剂量具有一定的镇痛作用（ P ＜0.01）。结论复方薰衣草油膏对烫伤皮肤创面有促愈合作用，同时具有一定的抗炎、镇痛作用。
목적：종염증반응적각도탐토외용복방훈의초유고대탕상돈서창면유합적영향병관찰기항염화진통작용。방법건립천Ⅱ도탕상돈서모형，장60지웅성돈서수궤분위정상조、모형조、경만홍조、복방훈의초유고고、중、저제량조，분별외용생리염수、경만홍연고、복방훈의초유고치료，관찰창면적대체변화급유합정황，취치료후적창면조직화혈액표본，진행조직병이학검사화매련면역법측정혈청TNF-α、IL-6、IL-8농도；채용이갑분이종창모형화뉴체법관찰복방훈의초유고적항염、진통작용。결과외용복방훈의초유고사창면종창、삼출감경，가능여국부조직중촉염세포인자수평적강저유관（P ＜0.01），병현저촉진돈서천Ⅱ도탕상창면적유합（P ＜0.01），미견임하부작용；고제량대이갑분소치소서이종창유억제작용（P ＜0.01）；뉴체법실험현시고제량구유일정적진통작용（ P ＜0.01）。결론복방훈의초유고대탕상피부창면유촉유합작용，동시구유일정적항염、진통작용。
Objective To study the main pharmacodynamics effect of compound lavender ointment on the scald, anti-inflammation and analgesia.Methods Sixty guinea pigs were divided into normal groups,model groups( superficialⅡ°scalding models) ,compound lavender ointment high,median,low dose groups,and jing wan hong ointment groups,then observation of the wounds and healing was made and recorded.Histopathological examination was made to examine the wounds,and ELISA to analyze serum TNF-α、IL-6、IL-8.Xylene ear swelling model and writhing test were used to observe the analgesic and anti-inflammatory effects of the compound lavender ointment.Results Compound lavender ointment can relieve the wounds swelling and exudation,which may be related to the decrease of proinflammatory cytokines(P <0.01), and promote the wound healing significantly( P <0.01) ,that the side-effects were not observed.High dose of compound lavender ointment can inhibit ear swelling and have certain analgesia with the writhing tests.Conclusion Compound lavender ointment have the promoting wound healing,anti-infectious and antalgic effects on the scald.