CAJ | 학술논문

目的：研究喜炎平注射液对比格犬心电图的影响。方法将24只比格犬随机分为阴性对照组（0 mg／kg）、低剂量组（15 mg／kg）、中剂量组（75 mg／kg）、高剂量组（250 mg／kg），每组6只，雌雄各半。每天一次，连续28 d静脉点滴喜炎平注射液，给药体积是20 mL／kg，并设置恢复期14 d。测定不同时期Ⅱ导联心电图。计算心率、P-R间期、Q-T间期、P波振幅、Q波振幅、R波振幅、S波振幅、ST振幅、T波振幅等指标，并同期取血测定血清生化学指标，观察对主要脏器的影响。结果检疫期，24犬心电图各项指标均在正常值范围之内。高剂量组P-R间期时间延长。给药中期，给药结束后及恢复期各项指标未见异常。结论喜炎平注射液对比格犬心电图无明显影响。
목적：연구희염평주사액대비격견심전도적영향。방법장24지비격견수궤분위음성대조조（0 mg／kg）、저제량조（15 mg／kg）、중제량조（75 mg／kg）、고제량조（250 mg／kg），매조6지，자웅각반。매천일차，련속28 d정맥점적희염평주사액，급약체적시20 mL／kg，병설치회복기14 d。측정불동시기Ⅱ도련심전도。계산심솔、P-R간기、Q-T간기、P파진폭、Q파진폭、R파진폭、S파진폭、ST진폭、T파진폭등지표，병동기취혈측정혈청생화학지표，관찰대주요장기적영향。결과검역기，24견심전도각항지표균재정상치범위지내。고제량조P-R간기시간연장。급약중기，급약결속후급회복기각항지표미견이상。결론희염평주사액대비격견심전도무명현영향。
Objective To study the effect of Xi Yanping injection on electrocardiogram in Beagle dogs.Methods 24 Beagle dogs were divided into negative control group (0 mg/kg), low-dose group (15 mg/kg), middle-dose group (75 mg/kg), high-dose group (250 mg/kg).Each group consist of 3 animals/sex/group, all animals were administrated by intravenous drip at 20 mL/kg once a day.Administration period was 28-days with 14-days recovery phase.Animals LeadⅡelectrocardiogram ( ECG) was measured during quanrantine, administration and recovery phase.The following parameters included heart rate, P -Rinterval, Q -T interval, P, Q, RS wave amplitude and ST and T wave amplitude were determined, serum biochemical parameters were measured to evaluate the effect on main organs.Results All parameters of quarantine period were fell in the normal limit.After the first administration, heart rate decrease was found in low dose group and P-Rinterval prolongation was found in high dose group.No abnormal was found in dose metaphase,end of dose stage and recovery stage.Conclusion Xi Yanping injection had no obvious influence on ECG of Beagle dog.