CAJ | 학술논문

目的：观察单倍体相合骨髓移植治疗白血病的造血重建效果。方法选择36例白血病患者作为研究对象，均采取单倍体相合骨髓移植方案进行治疗，对造血重建指标进行观察评估。结果所有患者均在接受骨髓移植后的3~7 d 内白细胞下降至0，中性粒细胞>0.5×109/ L 和血小板>20.0×109/ L 的时间分别为（17.5±0.9） d 和（21.5±0.7）d。所有患者3系造血均得到重建。结论骨髓供者通过人粒细胞集落刺激因子预处理后进行骨髓采集，联合多种免疫制剂，能够有效抑制 HLA 多样性屏障，提高白血病患者的造血重建效果，值得重视。
목적：관찰단배체상합골수이식치료백혈병적조혈중건효과。방법선택36례백혈병환자작위연구대상，균채취단배체상합골수이식방안진행치료，대조혈중건지표진행관찰평고。결과소유환자균재접수골수이식후적3~7 d 내백세포하강지0，중성립세포>0.5×109/ L 화혈소판>20.0×109/ L 적시간분별위（17.5±0.9） d 화（21.5±0.7）d。소유환자3계조혈균득도중건。결론골수공자통과인립세포집락자격인자예처리후진행골수채집，연합다충면역제제，능구유효억제 HLA 다양성병장，제고백혈병환자적조혈중건효과，치득중시。
ObJective:To observe the effect of hematopoietic reconstitution after haploidentical bone marrow transplanta-tion for treatment of leukemia. Methods:Thirty-six cases of leukemia patients as the research obJect received haploidentical bone marrow transplantation for treatment,and the assessment index of hematopoietic reconstitution was observed. Results:The white blood cells in all the patients after bone marrow transplant within 3 ~ 7d fell to 0. The median time of granulocyte counts > 0. 5 × 109 / L and platelet > 20. 0 × 109 / L was(17. 5 ± 0. 9)d and(21. 5 ± 0. 7)d,respectively. All patients a-chieved 3 hematopoietic reconstruction. Conclusion:Bone marrow donor with granulocyte colony-stimulating factor after pre-treatment bone marrow collection,combined with a variety of immune formulations,can effectively inhibit the HLA diversity barrier and improve hematopoietic reconstruction effect of leukemia patients,which is worthy of attention.