CAJ | 학술논문

目的：研究生姜与芦根的天然药物组合物在用于制备减少癌症放、化疗引起的呕吐副作用并对治疗癌症起增效作用的药物中的用途。方法用经典的水貂呕吐模型观察组合物的止吐作用；在小鼠肿瘤模型上探索了组合物的抑制肿瘤作用。结果证明该姜芦组合物对于顺铂所致水貂的呕吐反应有对抗作用（P <0.01）；并证明该组合物对于小鼠体内 S 180肉瘤、肝癌 H22、艾氏腹水瘤 EAC 也有抑制作用（P <0.01）。结论姜芦组合物有抑癌作用并减少抗癌药顺铂引起的呕吐作用。
목적：연구생강여호근적천연약물조합물재용우제비감소암증방、화료인기적구토부작용병대치료암증기증효작용적약물중적용도。방법용경전적수초구토모형관찰조합물적지토작용；재소서종류모형상탐색료조합물적억제종류작용。결과증명해강호조합물대우순박소치수초적구토반응유대항작용（P <0.01）；병증명해조합물대우소서체내 S 180육류、간암 H22、애씨복수류 EAC 야유억제작용（P <0.01）。결론강호조합물유억암작용병감소항암약순박인기적구토작용。
ObJective:To study the detoxification and synergistic effect of zingiber and rhizoma composite on radiothera-py and chemotherapy. Methods:The classic mink vomiting model was used to observe the antiemetic effect of the composi-tion,and then the mice tumor model was used to observe the antitumor effect of the composition. Results:The mink vomi-ting model proved that the composition significantly resisted mink vomiting response caused by cisplatin. The mice tumor model proved that the composition had obvious inhibition to the S180 ,H22 and EAC tumor in mice. Conclusion:The composi-tion can reduce vomiting side effects caused by radiotherapy and chemotherapy on cancer,and have synergistic effect in the treatment of cancer.