CAJ | 학술논문

目的：通过观察血浆神经肽 Y（NPY）在原发性高血压不同血压级别及原发性高血压合并靶器官损害患者中浓度的变化，探讨 NPY 在原发性高血压病理生理进程中的作用及在原发性高血压靶器官损害中的意义。方法选取200例在2012年1月-2013年1月于泰安市中心医院被确诊为原发性高血压患者，合并靶器官损害病人共111例，其中单一靶器官损害患者78例，2个或2个以上联合靶器官损害患者33例。50例健康人作为对照组。采空腹静脉血用放射免疫方法测定NPY 的浓度。结果单一靶器官损害组血浆NPY 浓度明显高于单纯高血压而无靶器官损害组。联合靶器官损害组血浆NPY 浓度明显高于单纯高血压而无靶器官损害组，而与单一靶器官损害组相比无显著性差异。结论原发性高血压合并不同靶器官损害患者均存在血浆NPY 浓度的异常升高，血浆NPY 可能促进了高血压靶器官损害的发生与发展，检测血浆NPY 浓度可作为评价高血压病程及靶器官损害程度的指标。
목적：통과관찰혈장신경태 Y（NPY）재원발성고혈압불동혈압급별급원발성고혈압합병파기관손해환자중농도적변화，탐토 NPY 재원발성고혈압병리생리진정중적작용급재원발성고혈압파기관손해중적의의。방법선취200례재2012년1월-2013년1월우태안시중심의원피학진위원발성고혈압환자，합병파기관손해병인공111례，기중단일파기관손해환자78례，2개혹2개이상연합파기관손해환자33례。50례건강인작위대조조。채공복정맥혈용방사면역방법측정NPY 적농도。결과단일파기관손해조혈장NPY 농도명현고우단순고혈압이무파기관손해조。연합파기관손해조혈장NPY 농도명현고우단순고혈압이무파기관손해조，이여단일파기관손해조상비무현저성차이。결론원발성고혈압합병불동파기관손해환자균존재혈장NPY 농도적이상승고，혈장NPY 가능촉진료고혈압파기관손해적발생여발전，검측혈장NPY 농도가작위평개고혈압병정급파기관손해정도적지표。
ObJective:To observe the changes of concentration in plasma neuropeptide Y in the patients of essential hy-pertension with different blood pressure levels and essential hypertension with target organ damage,and investigate the plas-ma neuropeptide Y in essential hypertension and the effect of physiological and pathological process in primary hypertensive target organ damage. Methods:200 cases during 2012 January ~ January 2013 in Taiˊan Central Hospital were diagnosed with primary hypertension,synthesis of target organ damage in patients with a total of 111 cases,including single target or-gan damage in patients with 78 cases and two or more than two combined target organ damage in 33 cases. Fifty cases of healthy people were used as the control group. Fasting venous blood concentration to NPY was determined by radioimmuno-assay method. Results:Plasma NPY concentration of single target organ damage was significantly higher than that in the group without target organ damage in the hypertension group. Plasma NPY concentration in the combined target organ dam-age was significantly higher than that in the group without target organ damage in hypertension group,and there was no sig-nificant difference compared with that of single target damage group. Conclusion:The concentration of plasma NPY is found in the abnormal primary hypertension with different target organ damage,which may promote the occurrence and develop-ment of hypertensive target organ damage,and the detection of plasma NPY concentration can be used as evaluation of hy-pertension and target organ damage index.