CAJ | 학술논문

目的：了解解脲支原体( ureaplasma urealyticum, Uu)和人型支原体( mycoplasma hominis, Mh)感染情况,分析支原体耐药趋势,为临床诊治提供依据。方法对2012年7月-2014年2月我院妇产科、泌尿外科和皮肤科门诊疑为泌尿生殖道感染1430例的泌尿生殖道分泌物标本进行支原体培养,同时行9种抗菌药物(多西环素、米诺环素、交沙霉素、克拉霉素、罗红霉素、阿奇霉素、氧氟沙星、左氧氟沙星和司帕沙星)的药物敏感试验。结果1430例标本中,支原体培养阳性788例(55.10%),以20~40岁患者为主占86.55%(682/788),阳性率女性高于男性(61.21%vs 27.24%,χ2=98.35,P<0．01)。其中Uu单一感染578例(40.42%),Mh单一感染10例(0.70%),Uu并Mh混合感染200例(13.99%)。支原体对多西环素和米诺环素的敏感率较高,分别为92.01%和92.89%；对氧氟沙星和罗红霉素的敏感率较低,分别为6.35%和8.76%。 Uu单一感染和Uu并Mh混合感染患者对9种抗生素药物敏感程度差异均有统计学意义(P均<0.01)。结论泌尿生殖道支原体感染率居高不下,耐药菌株不断增多,故临床医生应重视对支原体培养和药物敏感试验结果进行分析,动态掌握和监测支原体耐药性变化,合理使用敏感抗生素,最大限度地减少和预防支原体耐药。
목적：료해해뇨지원체( ureaplasma urealyticum, Uu)화인형지원체( mycoplasma hominis, Mh)감염정황,분석지원체내약추세,위림상진치제공의거。방법대2012년7월-2014년2월아원부산과、비뇨외과화피부과문진의위비뇨생식도감염1430례적비뇨생식도분비물표본진행지원체배양,동시행9충항균약물(다서배소、미낙배소、교사매소、극랍매소、라홍매소、아기매소、양불사성、좌양불사성화사파사성)적약물민감시험。결과1430례표본중,지원체배양양성788례(55.10%),이20~40세환자위주점86.55%(682/788),양성솔녀성고우남성(61.21%vs 27.24%,χ2=98.35,P<0．01)。기중Uu단일감염578례(40.42%),Mh단일감염10례(0.70%),Uu병Mh혼합감염200례(13.99%)。지원체대다서배소화미낙배소적민감솔교고,분별위92.01%화92.89%；대양불사성화라홍매소적민감솔교저,분별위6.35%화8.76%。 Uu단일감염화Uu병Mh혼합감염환자대9충항생소약물민감정도차이균유통계학의의(P균<0.01)。결론비뇨생식도지원체감염솔거고불하,내약균주불단증다,고림상의생응중시대지원체배양화약물민감시험결과진행분석,동태장악화감측지원체내약성변화,합리사용민감항생소,최대한도지감소화예방지원체내약。
Objective To investigate the infection situation and drug resistance tendency of ureaplasma urealyticum ( Uu) and mycoplasma hominis ( Mh) for improving clinical diagnosis and treatment. Methods During July 2012 and Febru-ary 2014, a total of 1430 patients with suspect urogenital tract infection from Department of Gynaecology and Obstetrics, Uri-nary Surgery and Outpatient Department of Dermatology in our hospital were detected of genitourinary tract secretions for myco-plasma cultivation, and sensitivity test was done to 9 antibacterial drugs, such as doxycycline, minocycline, josamycin, clar-ithromycin, roxithromycin, azithromycin, ofloxacin, levofloxacin, and sparfloxacin. Results There were 788 cases (55. 10%, 788/1430) of mycoplasma infection, and patients aged from 20-40 years accounted for 86. 55% (682/788). The positive rate in female patients was higher than that in male patients (61. 21% vs. 27. 24%,χ2 =98. 35, P<0. 01). There were 578 cases (40. 42%) of Uu infection, 10 cases (0. 70%) of Mh infection, and 200 cases (13. 99%) of mixed infection of Uu and Mh. Mycoplasma showed highest sensitivity to doxycycline (92. 01%) and minocycline (92. 89%), and showed lowest sensitivity to roxithromycin (8. 76%) and ofloxacin (6. 35%). The drug resistance rate showed significant difference between patients with Uu and Mh mixed infection and patients with single Uu infection (P<0. 01). Conclusion Mycoplasma infection rate is on rise and dug resistant strains increase gradually. Clinicians should pay attention to analysis of mycoplasma culture and drug sensitivity test, dynamically monitoring the drug resistance for rational use of antimicrobial agents and reduc-ing the spread of multi-drug resistant strains.