CAJ | 학술논문

目的：系统评价幽门螺杆菌感染与支气管哮喘之间关系。方法收集筛选研究幽门螺杆菌感染与支气管哮喘之间关系的文献,提取数据并进行定量综合分析。结果本次meta分析共纳入13篇文献,其中哮喘病例组3190例,对照组17118例。支气管哮喘组与对照组中的幽门螺杆菌感染率存在显著差异,合并比值比为0.87(95%CI：0.80,0.95),P=0．001。亚洲人群中幽门螺杆菌感染与支气管哮喘风险的合并 OR 值为0.93(95%CI：0.75,1．16),P=0．530；欧美人群中幽门螺杆菌感染与支气管哮喘风险的合并 OR 值为0.86(95%CI 0.79,0.94),P =0．001。结论幽门螺杆菌感染可降低支气管哮喘发病率,临床上还需开展更多的研究来证实上述结论。
목적：계통평개유문라간균감염여지기관효천지간관계。방법수집사선연구유문라간균감염여지기관효천지간관계적문헌,제취수거병진행정량종합분석。결과본차meta분석공납입13편문헌,기중효천병례조3190례,대조조17118례。지기관효천조여대조조중적유문라간균감염솔존재현저차이,합병비치비위0.87(95%CI：0.80,0.95),P=0．001。아주인군중유문라간균감염여지기관효천풍험적합병 OR 치위0.93(95%CI：0.75,1．16),P=0．530；구미인군중유문라간균감염여지기관효천풍험적합병 OR 치위0.86(95%CI 0.79,0.94),P =0．001。결론유문라간균감염가강저지기관효천발병솔,림상상환수개전경다적연구래증실상술결론。
Objective To systematically evaluate the relationship between helicobacter pylori ( H. pylori) infec-tion and bronchial asthma. Methods Literature search was conducted to select the related publications on the relation-ship between H. pylori infection and bronchial asthma, and retrieval data was processed with quantitative meta-analysis. Results Thirteen studies were included in the meta-analysis, which included 3190 patients in bronchial asthma group and 17118 in control group. The H. pylori infection rate was significantly different between bronchial asthma group and control group, and the pooled odd ratio (OR) was 0. 87 (95%CI:0. 80-0. 95, P=0. 001). The pooled ORs of H. pylo-ri infection and bronchial asthma risk were 0. 93 (95%CI:0. 75, 1. 16, P=0. 530) and 0. 86 (95%CI:0. 79, 0. 94, P=0. 001) in Asians and in European-American population respectively. Conclusion H. pylori infection may be asso-ciated with low risk of incidence rate of bronchial asthma, and further studies are needed to confirm the findings.