解放军医药杂志
解放軍醫藥雜誌
해방군의약잡지
MEDICAL&PHARMACEUTICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY
2014年
10期
62-65
,共4页
胃旁路术%糖尿病,2型%胰岛素%治疗结果
胃徬路術%糖尿病,2型%胰島素%治療結果
위방로술%당뇨병,2형%이도소%치료결과
Gastric bypass%Diabetes mellitus,type 2%Insulin%Treatment outcome
目的：探讨改良胃肠短路术(RYGB)治疗非肥胖2型糖尿病(T2DM)的有效性及安全性。方法回顾性分析2012年5月-2013年6月采用RYGB治疗15例非肥胖T2DM患者的临床资料,观察手术前后1个月糖耐量检查结果,术前及术后1、6个月时观察空腹血糖(FPG)、餐后2 h血糖(2 hPG)、空腹胰岛素(Fins)、糖化血红蛋白( HbAlc),计算胰岛素抵抗指数( HOMA-IR )及手术前后血糖达标情况及低血糖事件发生率。结果治愈率为73．3%。术后1个月本组血糖值均显著低于手术前(P<0．01)；本组术后1、6个月时FPG、2 hPG、HbAlc以及HOMA-IR等指标均显著低于术前(P<0．01),术后1个月与术后6个月检测值比较无统计学差异(P>0．05),Fins在手术前后未见明显变化(P>0．05)；术后1、6个月与术前比较血糖达标率及低血糖发生率差异均具有统计学意义(P <0．05)。结论 RYGB治疗非肥胖的T2DM是安全、有效的。
目的：探討改良胃腸短路術(RYGB)治療非肥胖2型糖尿病(T2DM)的有效性及安全性。方法迴顧性分析2012年5月-2013年6月採用RYGB治療15例非肥胖T2DM患者的臨床資料,觀察手術前後1箇月糖耐量檢查結果,術前及術後1、6箇月時觀察空腹血糖(FPG)、餐後2 h血糖(2 hPG)、空腹胰島素(Fins)、糖化血紅蛋白( HbAlc),計算胰島素牴抗指數( HOMA-IR )及手術前後血糖達標情況及低血糖事件髮生率。結果治愈率為73．3%。術後1箇月本組血糖值均顯著低于手術前(P<0．01)；本組術後1、6箇月時FPG、2 hPG、HbAlc以及HOMA-IR等指標均顯著低于術前(P<0．01),術後1箇月與術後6箇月檢測值比較無統計學差異(P>0．05),Fins在手術前後未見明顯變化(P>0．05)；術後1、6箇月與術前比較血糖達標率及低血糖髮生率差異均具有統計學意義(P <0．05)。結論 RYGB治療非肥胖的T2DM是安全、有效的。
목적：탐토개량위장단로술(RYGB)치료비비반2형당뇨병(T2DM)적유효성급안전성。방법회고성분석2012년5월-2013년6월채용RYGB치료15례비비반T2DM환자적림상자료,관찰수술전후1개월당내량검사결과,술전급술후1、6개월시관찰공복혈당(FPG)、찬후2 h혈당(2 hPG)、공복이도소(Fins)、당화혈홍단백( HbAlc),계산이도소저항지수( HOMA-IR )급수술전후혈당체표정황급저혈당사건발생솔。결과치유솔위73．3%。술후1개월본조혈당치균현저저우수술전(P<0．01)；본조술후1、6개월시FPG、2 hPG、HbAlc이급HOMA-IR등지표균현저저우술전(P<0．01),술후1개월여술후6개월검측치비교무통계학차이(P>0．05),Fins재수술전후미견명현변화(P>0．05)；술후1、6개월여술전비교혈당체표솔급저혈당발생솔차이균구유통계학의의(P <0．05)。결론 RYGB치료비비반적T2DM시안전、유효적。
Objective To investigate the efficacy and safety of modified Roux-en-Y gastric bypass (RYGB) in treatment of non-obese type 2 diabetes mellitus (T2DM). Methods Clinical data of 15 non-obese T2DM patients trea-ted with modified RYGB during May 2012 and June 2013 was retrospectively analyzed, and test results of glucose toler-ance in preoperative and postoperative 1 month were observed, and the indexes of fasting plasma glucose (FPG), 2 h postprandial glucose (2 hPG), fasting insulin (Fins), glycated hemoglobin (HbAlc) before the operation and in 1st and 6th month after the operation were also observed. The insulin resistance index(HOMA-IR), target situation of blood glu-cose and incidence rate of hypoglycemia before the operation and in 1st and 6th month after the operation were calculated. Results The recovery rate was 73. 3%. The glucose values of postoperative 1 month were significantly lower than those before operation (P<0. 01);the levels of FPG, 2 hPG, HbAlc and HOMA-IR were significantly decreased in 1st and 6th month after the operation, compared with those before the operation (P<0. 01);there were no significant differences in the levels between 1 st and 6 th month after the operation ( P>0. 05 ) , and the Fins level showed no significant difference before and after the operation (P>0. 05);the differences in values of target rate of blood glucose and incidence rate of hypoglycemia in 1st and 6th month after the operation, compared with those before the operation, were statistically signifi-cant (P<0. 05). Conclusion The modified Roux-en-Y gastric bypass in treatment of non-obese type 2 diabetes melli-tus is safe and effective.
