中国现代药物应用
中國現代藥物應用
중국현대약물응용
CHINESE JOURNAL OF MODERN DRUG APPLICATION
2014年
20期
9-10
,共2页
支气管肺灌洗%多重耐药%肺炎%纤维支气管镜
支氣管肺灌洗%多重耐藥%肺炎%纖維支氣管鏡
지기관폐관세%다중내약%폐염%섬유지기관경
Bronchoalveolar lavage%Multiple drug resistance%Pneumonia%Fiberoptic bronchoscopy
目的：对药物联合支气管肺灌洗的临床疗效进行讨论，观察该种治疗方式对肺部多重耐药感染的临床治疗效果，为日后的临床治疗推广提供参考。方法肺部多重耐药感染患者80例为研究对象，随机分为观察组与对照组，每组40例。对照组患者给予常规抗感染、营养支持等治疗方式；观察组患者在对照组基础上，联合纤维支气管镜(纤支镜)进行支气管肺灌洗。观察组患者每天灌洗1次，持续灌洗1周，观察两组患者的临床症状变化、实验室检查指标以及身体情况的变化。结果经过治疗后，发现观察组患者的体温下降比较明显，患者的痰量也大幅度下降，呼吸频率、动脉血氧分压等方面具有明显改善，患者身体状况趋于良好。在两组患者康复情况的对比中，观察组总有效率为95.0%，显著优于对照组77.5%，两组差异具有统计学意义(P<0.05)。观察组患者未出现死亡患者，而对照组患者有2例死亡。结论采用药物联合支气管肺灌洗的方式，不仅可以较大程度的缓解肺部多重耐药感染患者的病痛，还可以持续治疗疾病，逐步恢复正常的生理指标，对改善患者生活质量以及延长寿命、缩短住院时间具有积极意义。
目的：對藥物聯閤支氣管肺灌洗的臨床療效進行討論，觀察該種治療方式對肺部多重耐藥感染的臨床治療效果，為日後的臨床治療推廣提供參攷。方法肺部多重耐藥感染患者80例為研究對象，隨機分為觀察組與對照組，每組40例。對照組患者給予常規抗感染、營養支持等治療方式；觀察組患者在對照組基礎上，聯閤纖維支氣管鏡(纖支鏡)進行支氣管肺灌洗。觀察組患者每天灌洗1次，持續灌洗1週，觀察兩組患者的臨床癥狀變化、實驗室檢查指標以及身體情況的變化。結果經過治療後，髮現觀察組患者的體溫下降比較明顯，患者的痰量也大幅度下降，呼吸頻率、動脈血氧分壓等方麵具有明顯改善，患者身體狀況趨于良好。在兩組患者康複情況的對比中，觀察組總有效率為95.0%，顯著優于對照組77.5%，兩組差異具有統計學意義(P<0.05)。觀察組患者未齣現死亡患者，而對照組患者有2例死亡。結論採用藥物聯閤支氣管肺灌洗的方式，不僅可以較大程度的緩解肺部多重耐藥感染患者的病痛，還可以持續治療疾病，逐步恢複正常的生理指標，對改善患者生活質量以及延長壽命、縮短住院時間具有積極意義。
목적：대약물연합지기관폐관세적림상료효진행토론，관찰해충치료방식대폐부다중내약감염적림상치료효과，위일후적림상치료추엄제공삼고。방법폐부다중내약감염환자80례위연구대상，수궤분위관찰조여대조조，매조40례。대조조환자급여상규항감염、영양지지등치료방식；관찰조환자재대조조기출상，연합섬유지기관경(섬지경)진행지기관폐관세。관찰조환자매천관세1차，지속관세1주，관찰량조환자적림상증상변화、실험실검사지표이급신체정황적변화。결과경과치료후，발현관찰조환자적체온하강비교명현，환자적담량야대폭도하강，호흡빈솔、동맥혈양분압등방면구유명현개선，환자신체상황추우량호。재량조환자강복정황적대비중，관찰조총유효솔위95.0%，현저우우대조조77.5%，량조차이구유통계학의의(P<0.05)。관찰조환자미출현사망환자，이대조조환자유2례사망。결론채용약물연합지기관폐관세적방식，불부가이교대정도적완해폐부다중내약감염환자적병통，환가이지속치료질병，축보회복정상적생리지표，대개선환자생활질량이급연장수명、축단주원시간구유적겁의의。
Objective To investigate the clinical effect of drugs combined with bronchoalveolar lavage therapy, to observe the curative effect of the therapy in the treatment of lung multiple drug resistance infection, and to provide references for future clinical treatment. Methods A total of 80 cases of lung multiple drug resistance infection were randomly divided into observation group and control group with 40 cases in each group. The control group was treated by conventional anti infection and nutrition support treatment; and the observation group received bronchoalveolar lavage through fiberoptic bronchoscopy in addition. The lavage conducted 1 time a day, and lasted for 1 week. The change of clinical symptoms, index of laboratory examination and physical condition were observed. Results After treatment, temperature and amount of phlegm of patients in the observation group were decreased obviously, and their respiratory rate and arterial partial pressure of oxygen had significantly improved. Physical condition of patients tended to be good. Comparison between the recovery condition of the two groups showed that the total effective rate of the observation group was 95.0%, and that of the control group was 77.5%. The difference was statistically significant (P<0.05). There was no death case in the observation group, while 2 death cases in the control group. Conclusion Applying drugs combined with bronchoalveolar lavage therapy can not only relive the pain of lung multiple drug resistance infection, but also provide continuously treatment and improve physiological index gradually. The therapy is significant for improving patients’life quality, prolonging life, and shortening hospital stays.
